Lansoprazole Raises Somatostatin, Calcitonin Gene-Related Peptide, and Substance P Levels in Healthy Human Plasma

Katagiri, Fumihiko; Inoue, Shintaro; Sato, Yuhki; Takeyama, Masaharu

doi:10.1248/jhs.51.294

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…2) In recent years, some antiulcer medicines have 3,4) Furthermore, we revealed that single administration of the PPIs omeprazole and lansoprazole alter gastrointestinal peptides. 5,6) These results indicate new pharmacological effects of the medicines.…”

Section: Introductionmentioning

confidence: 79%

Effects of Rabeprazole on Plasma Gastrointestinal Peptides in Healthy Humans

Katagiri

Sato

Takeyama

2005

JOURNAL OF HEALTH SCIENCE

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Rabeprazole sodium (rabeprazole), a proton pump inhibitor (PPI), is widely used in the treatment of peptic ulcer and gastroesophageal reflux disease. Recently, some antiulcer medicines have been elucidated pharmacologically from the viewpoint of gut-regulated hormone levels. We examined the effects of rabeprazole on plasma levels of gastrointestinal peptides [gastrin, somatostatin, motilin, substance P, and calcitonin generelated peptide (CGRP)]. Rabeprazole at a dose of 20 mg or placebo was orally administered to 5 healthy male volunteers aged 25-30 years. Venous blood samples were taken before and 30, 60, 90, 120, 180, 240, and 360 min after administration. Plasma peptide levels were measured using a sensitive enzyme immunoassay. Compared with the response of the placebo group, rabeprazole caused significant (p < 0.05) increases in gastrin-, somatostatin-, and CGRP-like immunoreactive substance (IS) at 360, 180, and 240 min, respectively. Rabeprazole significantly decreased motilin-IS levels at 180 min compared with the placebo group. However, rabeprazole had no effect on plasma substance P-IS levels. Although rabeprazole has potent antisecretry effects, the agent may have little effect on gastrointestinal peptides.

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Section: Introductionmentioning

confidence: 79%

Effects of Rabeprazole on Plasma Gastrointestinal Peptides in Healthy Humans

Katagiri

Sato

Takeyama

2005

JOURNAL OF HEALTH SCIENCE

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Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea

Zheng,

Srinual,

Chen

et al. 2023

CDM

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Background: Chemotherapeutic drugs used in cancer treatment often result in gastrointestinal toxicity, notably diarrhea, impacting patients’ quality of life. Complementary and Alternative Medicine (CAM) has garnered increasing interest as an alternative to conventional approaches as a potential solution for managing chemotherapy-induced diarrhea (CID). Objective: To summarize current research focusing on herbal medicines as adjuvant therapy to prevent or treat chemotherapy-induced diarrhea, including clinical assessments, mechanism of actions, active components, and potential pharmacokinetic interactions between herbal medicines and chemotherapeutic drugs. Methods: We performed the literature review from PubMed, CNKI, Google Scholar, Web of Science, and Scopus using “Chemotherapy”, “Diarrhea,” and “Complementary and Alternative Medicine” as the search keywords. Results: Using herbal medicines as adjuvants provides an effective approach to treating or preventing CID with improved or unaffected antitumor activity of chemotherapeutic drugs. Among these herbal formulations, scutellaria, ginger, and ginseng are the most frequently used herbs in the prescriptions for CID. The main antidiarrheal components in herbs are wogonin, baicalin, chrysin, quercetin, gingerol, and ginsenosides. These herbs, formulations, and bioactive components relieved CID through different mechanisms, including directly decreasing local drug exposure, anti-inflammation, inhibiting epithelial apoptosis, or promoting epithelium stem cell regeneration. The application of herbal medicines as adjunctive therapies showed efficacy in preventing or treating CID in multiple clinical trials. However, more well-designed clinical studies are expected to validate the results further. Despite some clinical studies demonstrating that certain herbal medicines could potentially attenuate CID and improve efficacy, it remains necessary to evaluate herbal safety. The interactions between herbs and drugs are also potential concerns, but few clinical trials have focused on investigating this aspect. Conclusion: In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities brought on by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate their efficacy, ensure safety, and explore potential drug-herb interactions.

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Lansoprazole Raises Somatostatin, Calcitonin Gene-Related Peptide, and Substance P Levels in Healthy Human Plasma

Cited by 2 publications

References 25 publications

Effects of Rabeprazole on Plasma Gastrointestinal Peptides in Healthy Humans

Effects of Rabeprazole on Plasma Gastrointestinal Peptides in Healthy Humans

Herbal Medicines as Adjuvants for the Treatment of Chemotherapy-Induced Diarrhea

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