Lanthanide‐Doped Multicolor GdF<sub>3</sub> Nanocrystals for Time‐Resolved Photoluminescent Biodetection

Ju, Qiang; Liu, Yongsheng; Tu, Datao; Zhu, Haomiao; Li, Renfu; Chen, Xueyuan

doi:10.1002/chem.201101170

Cited by 109 publications

(82 citation statements)

References 89 publications

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“…[1][2][3][4] To date, many efforts have been dedicated to fabricating GdF 3 nanoparticles with various sizes and morphologies. [1][2][3][4] To date, many efforts have been dedicated to fabricating GdF 3 nanoparticles with various sizes and morphologies.…”

Section: Introductionmentioning

confidence: 99%

Doping alkaline-earth: a strategy of stabilizing hexagonal GdF3 at room temperature

et al. 2013

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Hexagonal GdF3 is a more efficient phosphor host compared with the traditional orthorhombic form but the hexagonal phase is thermodynamically unstable at room temperature. Herein, we present a strategy to stabilize hexagonal GdF3 by doping with alkaline-earth ions in a mild hydrothermal reaction system. The selection of the dopant, effect of the dopant amount and the mechanism of the phase transition was discussed in detail. The luminescence variation of GdF3:Eu was demonstrated to verify the phase transformation. Furthermore, the upconversion luminescence of the Sr-doped and undoped GdF3:Yb/Er was investigated.

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Section: Introductionmentioning

confidence: 99%

Doping alkaline-earth: a strategy of stabilizing hexagonal GdF3 at room temperature

et al. 2013

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“…The decay time of the green and red emission bands depends on the concentrations of the Yb and Er in the phosphor and a more detailed analysis is underway. In time gated fluorescence based biomaging, 43 longer decay time is a favorable factor to discriminate the noises arising from scattered light and autofluorescence.…”

Section: Resultsmentioning

confidence: 99%

Multimodal bioimaging using a rare earth doped Gd2O2S:Yb/Er phosphor with upconversion luminescence and magnetic resonance properties

et al. 2013

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While infrared upconversion imaging using halide nanoparticles are so common the search for a very efficient halide free upconverting phosphors is still lacking. In this article we report Gd2O2S:Yb/Er,YbHo,YbTm systems as a very efficient alternative phosphors that show upconversion efficiency comparable or even higher than existing halide phosphors. While the majority of rare earth dopants provide the necessary features for optical imaging, the paramagnetic Gd ion also contributes to the magnetic imaging,thereby resulting in a system with bimodal imaging features. Results from imaging of the nanoparticles together with aggregates of cultured cells have suggested that imaging of the particles in living animals may be possible. In vitro tests revealed no signficant toxicity because no cell death was observed when the nanoparticles were in the presence of growing cells in culture. Measurement of the magnetization of the phosphor shows that the particles are strongly magnetic, thus making them suitable as an MRI agent.

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“…8a) [26]. It was observed that the steady-state PL spectrum for the mixture of GdF 3 : Dy 3+ and RBITC was dominated by the emission of RBITC upon excitation at 272 nm, whereas only the Dy 3+ emission from the NPs was detected in the TRPL spectrum with a delay time of 50 μs and a gate time …”

Section: Time-resolved Luminescent Bioassaymentioning

confidence: 99%

“…Therefore, they are emerging as promising next-generation luminescent nano-bioprobes for versatile biomedical applications. Particularly, the long-lived downshifting luminescence (DSL) and high photochemical stability of Ln 3+ -doped NPs make them ideal alternative to Ln 3+ -chelates for TRPL biodetection to eliminate the short-lived background noise from scattered lights and autofluorescence from the biological samples [26,27]. Such unwanted background noise can also be overcome by using the unique anti-Stokes upconverting luminescence (UCL) and persistent luminescence of Ln This review summarizes the most recent advances in the development of inorganic lanthanide nano-bioprobes and their salient applications for background-free luminescent bioassays.…”

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confidence: 99%

Inorganic lanthanide nanoprobes for background-free luminescent bioassays

Huang

Zheng

et al. 2015

Sci. China Mater.

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Luminescent bioassay techniques have been widely adopted in a variety of research and medical institutions. However, conventional luminescent bioassays utilizing traditional bioprobes like organic dyes and quantum dots often suffer from the interference of background noise from scattered lights and autofluorescence from biological matrices. To eliminate this disadvantage, the use of inorganic lanthanide (Ln 3+ )-doped nanoparticles (NPs) is an excellent option in view of their superior optical properties, such as the long-lived downshifting luminescence, near-infrared triggered anti-Stokes upconverting luminescence and excitation-free persistent luminescence. In this review, we summarize the latest advances in the development of inorganic Ln 3+ -doped NPs as sensitive luminescent bioprobes from their fundamental physicochemical properties to biodetection, including the chemical synthesis, surface functionalization, optical properties and their promising applications for background-free luminescent bioassays. Future efforts and prospects towards this rapidly growing field are also proposed. INTRODUCTIONSensitive and specific bioassay of trace amount of target analytes is essential for a variety of biomedical applications ranging from pharmaceutical preparation to disease diagnosis and therapy [1][2][3]. Among various bioassay methods, luminescent bioassay has received particular attention because of its high sensitivity and good specificity [4,5]. Conventional luminescent bioassay techniques such as enzyme-linked immunosorbent assay (ELISA), time-resolved (TR) fluoroimmunoassay (TRFIA), Förster resonance energy transfer (FRET) and TR-FRET assays have laid the foundation for many modern clinical applications [6][7][8][9][10][11]. However, these bioassays are impeded by the availability of traditional bioprobes like organic dyes, lanthanide (Ln 3+ ) chelates and quantum dots (QDs). The use of these bioprobes has a number of limitations. Organic dyes commonly possess poor photochemical stability and suffer from serious photobleaching [12]. The applicability of QDs is compromised by photoblinking and high toxic- ity of heavy metal elements like cadmium and selenium, especially for in vivo biosensing [13,14]. Moreover, both organic dyes and QDs may induce high background noise and considerable photodamage to the biological samples under ultraviolet (UV) excitation, which deteriorates their detection sensitivity for bioassays [15,16]. Although such background noise can be suppressed by the technique of TR photoluminescence (PL) through the use of the longlived luminescence of Ln 3+ -chelates, the poor photochemical stability, long-term toxicity and high cost of Ln 3+ -chelates remain a major issue [17]. These concerns fuel a crucial demand for the development of a new generation of luminescent bioprobes to circumvent the limitations of traditional ones.Recently, with the explosion of nanoscience and nanotechnology, there is a growing dedication towards the development of diverse luminescent nanoprobes for biodetection ...

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Lanthanide‐Doped Multicolor GdF₃ Nanocrystals for Time‐Resolved Photoluminescent Biodetection

Cited by 109 publications

References 89 publications

Doping alkaline-earth: a strategy of stabilizing hexagonal GdF3 at room temperature

Doping alkaline-earth: a strategy of stabilizing hexagonal GdF3 at room temperature

Multimodal bioimaging using a rare earth doped Gd2O2S:Yb/Er phosphor with upconversion luminescence and magnetic resonance properties

Inorganic lanthanide nanoprobes for background-free luminescent bioassays

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Lanthanide‐Doped Multicolor GdF3 Nanocrystals for Time‐Resolved Photoluminescent Biodetection

Cited by 109 publications

References 89 publications

Doping alkaline-earth: a strategy of stabilizing hexagonal GdF3 at room temperature

Doping alkaline-earth: a strategy of stabilizing hexagonal GdF3 at room temperature

Multimodal bioimaging using a rare earth doped Gd2O2S:Yb/Er phosphor with upconversion luminescence and magnetic resonance properties

Inorganic lanthanide nanoprobes for background-free luminescent bioassays

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Lanthanide‐Doped Multicolor GdF₃ Nanocrystals for Time‐Resolved Photoluminescent Biodetection