Lanthanide-Doped Nanoparticles for Diagnostic Sensing

Lee, Song Yeul; Lin, Min; Lee, Ruda; Park, Yong Il

doi:10.3390/nano7120411

Cited by 47 publications

(27 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The output of quick progress in the manufacturing and design of materials in the nanometer-scale has resulted in different types of nanoparticles (NPs) with different physical/chemical properties, shapes, and sizes. Lanthanide-doped NPs, so-called upconversion NPs (UCNPs), are a class of fluorophore NPs that convert near-infrared (NIR) wavelengths to visible (Vis) or ultraviolet (UV) wavelengths with the assistant of dopant activators or emitter elements in the core of nanocrystals [6][7][8]. Using UCNPs in bioimaging provides various advantages in comparison with other common fluorophores such as quantum dots (QDs), gold NPs, and organic dyes.…”

Section: Introductionmentioning

confidence: 99%

Empowering the Emission of Upconversion Nanoparticles for Precise Subcellular Imaging

Rostami

2021

Nanomaterials

View full text Add to dashboard Cite

Upconversion nanoparticles (UCNPs) are a class of inorganic fluorophores that follow the anti-Stokes mechanism, to which the wavelength of emission is shorter than absorption. This unique optical behavior generates relatively long-lived intermediate energy levels of lanthanides that stabilize the excitation state in the fluorescence process. Longer-wavelength light sources, e.g., near-infrared (NIR), penetrate deeper into biological materials such as tissue and cells that provide a larger working space for cell biology applications and imaging, whereby UCNPs have recently gained increasing interest in medicine. In this report, the emission intensity of a gadolinium-based UCNP was screened by changing the concentrations of the constituents. The optimized condition was utilized as a luminescent nanoprobe for targeting the mitochondria as a distinguished subcellular organelle within differentiated neuroblastoma cells. The main goal of this study is to illustrate the targeting process within the cells in a native state using modified UCNPs. Confocal microscopy on the cells treated with the functionalized UCNPs indicated a selective accumulation of UCNPs after immunolabeling. To tackle the insolubility of as-synthesized particles in water-based media, the optimized UCNPs were surface-coated with polyamidoamine (PAMAM) dendrimers that due to peripheral amino groups are suitable for functionalizing with peptides and antibodies. Ultimately, we concluded that UCNPs are potentially versatile and ideal tools for NIR bioimaging and capable of making adequate contrast against biomaterials to be detectable in electron microscopy (EM) imaging.

show abstract

Section: Introductionmentioning

confidence: 99%

Empowering the Emission of Upconversion Nanoparticles for Precise Subcellular Imaging

Rostami

2021

Nanomaterials

View full text Add to dashboard Cite

show abstract

“…These luminescence properties make Ln 3+ interesting candidates for the usage as luminescent stains in many materials: their emission bands are very sharp and they exhibit long luminescence lifetimes in the range of several milliseconds, which make them superior to organic dyes 16,17. Ln 3+ ‐doped micro‐ and nanoparticles are powerful tools for many applications; they may serve as tracking assays, imaging probes for biomedical applications, or in microoptics 18–23. Ln 3+ , including Tb 3+ , have the same ionic radii as calcium ions (Ca 2+ ), thus they can replace the Ca 2+ and might be incorporated in calcite, which then functions as host‐lattice 16,24.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Shaping of Inorganic Functional Devices using Microalgae

2020

View full text Add to dashboard Cite

The usage of biomineralization processes performed by living microalgae to create 3D nanostructured materials are advantageous compared to conventional synthesis routes. Exploitation of in vivo shaping using living cells leads to inorganic intricate biominerals, produced with low environmental impact. Since biomineralization processes are genetically controlled, the formation of nanostructured materials is highly reproducible. The shells of microalgae, like coccoliths, are particularly of great interest. This study shows the generation of mesoporous highly structured functional materials with induced optoelectronical properties using in vivo processes of the microalga species Emiliania huxleyi. It demonstrates the metabolically driven incorporation of the lanthanide terbium into the coccoliths of E. huxleyi as a route for the synthesis of finely patterned photoluminescent particles by feeding the microalgae with this luminescent element. The resulting green luminescent particles have hierarchical ordered pores on the nano‐ and microscale and may act as powerful tools for many applications; they may serve as imaging probes for biomedical applications, or in microoptics. The luminescent coccoliths combine a unique hierarchical structure with a characteristic luminescence pattern, which make them superior to conventional produced Tb doted material. With this study, the possibility of the further exploitation of coccoliths as advanced functional materials for nanotechnological applications is given.

show abstract

“…So far, few review articles have been published on UCNP and their applications. However, these reviews specifically focused either on synthesis approaches, biomedical applications like, imaging, therapeutic, sensing, or other applications in specific field. However, here in this review, we present a comprehensive overview by discussing the fundamental concepts, including the different mechanisms proposed for explaining the upconversion processes, followed by the different strategies employed for the synthesis of these materials and finally the most recent advances of UCNP for bioimaging, drug delivery, sensing, and photocatalysis applications.…”

Section: Introductionmentioning

confidence: 99%

Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications

Reddy

Balaji

Kumar

et al. 2018

Small

116

View full text Add to dashboard Cite

Near infrared (NIR) light utilization in a range of current technologies has gained huge significance due to its abundance in nature and nondestructive properties. NIR active lanthanide (Ln) doped upconversion nanomaterials synthesized in controlled shape, size, and surface functionality can be combined with various pertinent materials for extensive applications in diverse fields. Upconversion nanophosphors (UCNP) possess unique abilities, such as deep tissue penetration, enhanced photostability, low toxicity, sharp emission peaks, long anti-Stokes shift, etc., which have bestowed them with prodigious advantages over other conventional luminescent materials. As new generation fluorophores, UCNP have found a wide range of applications in various fields. In this Review, a comprehensive overview of lanthanide doped NIR active UCNP is provided by discussing the fundamental concepts including the different mechanisms proposed for explaining the upconversion processes, followed by the different strategies employed for the synthesis of these materials, and finally the technological applications of UCNP, mainly in the fields of bioimaging, drug delivery, sensing, and photocatalysis by highlighting the recent works in these areas. In addition, a brief note on the applications of UCNP in other fields is also provided along with the summary and future perspectives of these materials.

show abstract

Lanthanide-Doped Nanoparticles for Diagnostic Sensing

Cited by 47 publications

References 70 publications

Empowering the Emission of Upconversion Nanoparticles for Precise Subcellular Imaging

Empowering the Emission of Upconversion Nanoparticles for Precise Subcellular Imaging

In Vivo Shaping of Inorganic Functional Devices using Microalgae

Lanthanide Doped Near Infrared Active Upconversion Nanophosphors: Fundamental Concepts, Synthesis Strategies, and Technological Applications

Contact Info

Product

Resources

About