Lanthanide Upconversion Nanoplatforms for Advanced Bacteria‐Targeted Detection and Therapy

Li, Zhuo; Lu, Shan; Li, Xingjun; Chen, Zhuo; Chen, Xueyuan

doi:10.1002/adom.202202386

Cited by 10 publications

(7 citation statements)

References 139 publications

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“…[154] With the ability to absorb light at the NIR region, UCNPs could help to achieve deeper tissue penetration with low interference from blood and biological tissues. [155,156] As illustrated in Figure 3C, Wang and co-workers developed coreshell nanostructures of upconversion nanoparticles and TiO 2 (UCNPs@TiO 2 ) and studied its inhibitory effects against periodontitis-related pathogens. [103] Upconversion fluorescence-induced APDT treatment upon irradiation with a 980 nm NIR laser emitted an intense UV light, further triggering TiO 2 via an energy transfer to bring about remarkable antibacterial effects and vast reduction in metabolic activities of the biofilms.…”

Section: Periodontitismentioning

confidence: 99%

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Xin

Kwek

et al. 2023

ChemPlusChem

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The emergence of multi‐drug resistant bacteria strains has been an uphill battle in modern healthcare worldwide, due to the increasing difficulty of killing them. The evolving pathogenicity of bacteria has led to researchers searching for more effective antimicrobial therapeutics to successfully eliminate them without undesirable consequences to the human body. In recent years, antimicrobial photodynamic therapy (APDT), an obsolete technique for cancer treatments, has been reported to eradicate bacteria and biofilm‐related infections. The principle of antimicrobial photodynamic therapy solely relies on the photosensitizers (PSs) generating reactive oxygen species, in the presence of oxygen and light, to destroy pathogens. Thus, it can target a broad spectrum of microorganisms, owing to the indirect interaction between PSs and the bacteria, resulting in the less likelihood for the development of drug resistant bacteria strains. This review will focus on the recent progress of APDT in the last five years and some future perspectives of APDT. The mechanism of APDT against bacteria and biofilms, various PSs used for APDT, and some common multidrug‐resistant bacteria strains will be briefly introduced. The reported in vivo applications of APDT in the several types of bacterial infections that includes periodontitis, wound infections, keratitis, endophthalmitis and tuberculosis in the last five years will be summarized in detail.

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Section: Periodontitismentioning

confidence: 99%

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Xin

Kwek

et al. 2023

ChemPlusChem

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“…Imagining an ideal nanoparticle for bioapplications, one would likely create a multifunctional nanoplatform that not only has therapeutic functions enabling, for example, PDT or optogenetics, but also contains a targeting entity. [63][64][65][66][67] A protein corona significantly limits functionality, especially with respect to targeting. This is confirmed by a comparative study of the targeting efficiencies achieved to date.…”

Section: Challenges In Surface Chemistrymentioning

confidence: 99%

Control of Luminescence and Interfacial Properties as Perspective for Upconversion Nanoparticles

Schroter,

Hirsch

2023

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Near‐infrared (NIR) light is highly suitable for studying biological systems due to its minimal scattering and lack of background fluorescence excitation, resulting in high signal‐to‐noise ratios. By combining NIR light with lanthanide‐based upconversion nanoparticles (UCNPs), upconversion is used to generate UV or visible light within tissue. This remarkable property has gained significant research interest over the past two decades. Synthesis methods are developed to produce particles of various sizes, shapes, and complex core–shell architectures and new strategies are explored to optimize particle properties for specific bioapplications. The diverse photophysics of lanthanide ions offers extensive possibilities to tailor spectral characteristics by incorporating different ions and manipulating their arrangement within the nanocrystal. However, several challenges remain before UCNPs can be widely applied. Understanding the behavior of particle surfaces when exposed to complex biological environments is crucial. In applications where deep tissue penetration is required, such as photodynamic therapy and optogenetics, UCNPs show great potential as nanolamps. These nanoparticles can combine diagnostics and therapeutics in a minimally invasive, efficient manner, making them ideal upconversion probes. This article provides an overview of recent UCNP design trends, highlights past research achievements, and outlines potential future directions to bring upconversion research to the next level.

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“…UCNP is well-known for its low toxicity, high signal-tonoise ratio, low fluorescence background, and high penetration depth. [22][23][24][25][26][27][28][29][30] Hydrophilic UCNP can be obtained by the modification of soluble polymers. In this work, a PDA-functionalized UCNP was developed and tested.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Imaging and Photodynamic‐Enhanced Photothermal Inhibition of Cancer Cells Using a Multifunctional System Combining Indocyanine Green and Polydopamine‐Preloaded Upconversion Luminescent Nanoparticles

Ye,

Zhang,

Shen

et al. 2023

Macromol. Rapid Commun.

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This paper introduces a novel multifunctional system called UPIPF (upconversion‐polydopamine‐indocyanine‐polyethylene‐folic) for upconversion luminescent (UCL) imaging of cancer cells using near‐infrared (NIR) illumination. The system demonstrates efficient inhibition of human hepatoma (HepG2) cancer cells through a combination of NIR‐triggered photodynamic therapy (PDT) and enhanced photothermal therapy (PTT). Initially, upconversion nanoparticles (UCNP) have been synthesized using a simple thermal decomposition method. To improve their biocompatibility and aqueous dispersibility, polydopamine (PDA) has been introduced to the UCNP via a ligand exchange technique. Indocyanine green (ICG) molecules have been electrostatically attached to the surface of the UCNP‐polydopamine (UCNP@PDAs) complex to enhance the PDT and PTT effects. Moreover, polyethylene glycol (PEG)‐modified folic acid (FA) has been incorporated into the UCNP‐polydopamine‐indocyanine‐green (UCNP@PDA‐ICGs) nanoparticles to enhance their targeting capability against cancer cells. The excellent UCL properties of these UCNP enable the final UCNP@PDA‐ICG‐PEG‐FA nanoparticles (referred to as UPIPF) to serve as a potential candidate for the efficient anticancer drug delivery, real‐time imaging and early diagnosis of cancer cells. Furthermore, the UPIPF system exhibits PDT‐assisted PTT effects, providing a convenient approach for efficient cancer cell inhibition (more than 99% cells were killed). The prepared UPIPF system shows promise for early diagnosis and simultaneous treatment of malignant cancers.This article is protected by copyright. All rights reserved

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Lanthanide Upconversion Nanoplatforms for Advanced Bacteria‐Targeted Detection and Therapy

Cited by 10 publications

References 139 publications

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Antimicrobial Photodynamic Therapy for the Remote Eradication of Bacteria

Control of Luminescence and Interfacial Properties as Perspective for Upconversion Nanoparticles

Simultaneous Imaging and Photodynamic‐Enhanced Photothermal Inhibition of Cancer Cells Using a Multifunctional System Combining Indocyanine Green and Polydopamine‐Preloaded Upconversion Luminescent Nanoparticles

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