1979
DOI: 10.1007/bf00333617
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Lanthanon-induced hepatotoxicity and its prevention by pretreatment with the same lanthanon

Abstract: Intravenous injection of the light lanthanon praseodymium nitrate (10 mg/kg) into rats causes a marked liver toxicity which becomes manifest in hypoglycemia, inhibition of RNA and protein synthesis and accumulation of fat in liver tissue. All these effects can be nearly abolished by pretreating rats with a small dose (5 mg/kg) of the same lanthanon. This is neither due to a decreased uptake into the liver nor to an increased excretion rate of the lanthanon. It is assumed that the pretreatment may increase unsp… Show more

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Cited by 11 publications
(4 citation statements)
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“…Pr is the most toxic element leading to animal death in comparable concentrations used for Ce, probably due to its low clearing rate 17 . However, a pretreatment with low doses can prevent the lethal effect nearly complete 49 . All these elements have been shown to induce chromosome aberrations in the mouse in vivo 50 .…”
Section: Discussionmentioning
confidence: 99%
“…Pr is the most toxic element leading to animal death in comparable concentrations used for Ce, probably due to its low clearing rate 17 . However, a pretreatment with low doses can prevent the lethal effect nearly complete 49 . All these elements have been shown to induce chromosome aberrations in the mouse in vivo 50 .…”
Section: Discussionmentioning
confidence: 99%
“…The first three RE decreased RNA polymerase II activity while the latter three RE increased the activity; only Pr and Nd nitrates decreased RNA polymerase I activity while the other four did not change the RNA polymerase I activity. Otherwise, the biochemical changes are consistent among RE; those biochemical changes are increase in triglyceride in the liver (105,110,113,117) and increases in leakage of hepatic enzymes into blood (46,105,(111)(112)(113)(114)(115)(116). RE-induced hepatic injury seems to reduce P450 content and P450-related enzyme activities in rat (113) and mouse (109,119); however, the decreases in P450 activities (coumarin 7-hydroxylase and 7-ethoxyresorufin O-deethylase) at 3 to 4 days after iv injection of CeCI3 were preceded by increases in these enzyme activities at 1 to 2 days postinjection in DBA/2 mice (109,119).…”
Section: Exposure To Rare Earthsmentioning
confidence: 92%
“…The first three RE decreased RNA polymerase II activity while the latter three RE increased the activity; only Pr and Nd nitrates decreased RNA polymerase I activity while the other four did not change the RNA polymerase I activity. Otherwise, the biochemical changes are consistent among RE; those biochemical changes are increase in triglyceride in the liver (105,110,113,117) and increases in leakage of hepatic enzymes into blood (46,105,(111)(112)(113)(114)(115)(116). RE-induced hepatic injury seems to reduce P450 content and P450-related enzyme activities in rat (113) and mouse (109,119); however, the decreases in P450 activities (coumarin 7-hydroxylase and 7-ethoxyresorufin O-deethylase) at 3 to 4 days after iv injection of CeCI3 were preceded by increases in these enzyme activities at 1 to 2 days postinjection in DBA/2 mice (109,119).…”
Section: Toxicitymentioning
confidence: 92%