Lanthanum(III) and neodymium(III) complexes with anti-inflammatory drug sulindac: Synthesis, characterization, thermal investigation using coupled techniques TG-FTIR, and in vitro biological studies

Guerra, Renan Barrach; Fraga-Silva, Thais Fernanda de Campos; Aguiar, Julia; Oshiro, Paula Beatriz; Holanda, Bruno B.C.; Venturini, James; Bannach, Gilbert

doi:10.1016/j.ica.2019.119408

Cited by 8 publications

(2 citation statements)

References 41 publications

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“…Figure 2c,d shows the two‐dimensional network structure and three‐dimensional stacking diagram of the three complexes. [ 42 ] Experimental and simulated powder X‐ray diffraction (PXRD) patterns of [Ln 2 (L) 3 ·H 2 O] n were obtained (Figure S1). The results show that the diffraction peaks of the synthesized [Ln 2 (L) 3 ·H 2 O] n and the simulated peaks are in good agreement, which proves that the phase of [Ln 2 (L) 3 ·H 2 O] n is pure.…”

Section: Resultsmentioning

confidence: 99%

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Liu

et al. 2021

Applied Organom Chemis

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In this work, three new complexes [Ln2(L)3·H2O]n (where Ln = Nd(1)、Eu (2) and Sm (3)) have been synthesized by H2L (H2L = 1,1 ‘(1,4‐phenylene‐ bis [methylene])‐bis (pyridine‐3‐carboxylicaicd)) and were characterized by X‐ray single crystal diffraction and PXRD. The interaction of these complexes with FS DNA (fish sperm DNA) and the DNA binding constants of the complexes were determined using UV spectroscopy, indicating their ability to bind to FS DNA. The DNA binding constants k of the three complexes were 1.0186 × 104, 5.047 × 103, and 5.115 × 103, respectively. The results of UV spectrum showed that the complex 1–3 was bound to DNA through hydrogen bonding. The interaction of the complexes with FS DNA was studied by fluorescence spectroscopy. The stern‐volmer quenching values of complexes 1, 2, and 3 were 0.186, 0.093, and 0.114, respectively. Electrophoresis experiments showed that the three complexes could cleave DNA molecules. In addition, flow cytometry, and morphological apoptosis studies showed that the complex could induce apoptosis of HeLa tumor cells. Results all the three complexes had potential medicinal value.

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Section: Resultsmentioning

confidence: 99%

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Liu

et al. 2021

Applied Organom Chemis

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“…Lanthanide ions are the subject of increasing interest in bioinorganic and coordination chemistry 20,21 . Literature studies showed that complexes of lanthanides are associated with several biological properties such as cytotoxic effect and anticancer effect 19,[22][23][24][25][26] . Kostova group reported the antineoplastic activity of lanthanide complex compounds with 3,3'-benzylidenebis[4-hydroxycoumarin] 27 .…”

Section: Introductionmentioning

confidence: 99%

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2021

IJPSR

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Hybrid molecules, furnished by combining coumarin and pyrazoles, have been synthesized in the present study. In addition, the binding ability of these coumarin-based molecules has been investigated for Nickel and less studied lanthanum. Lanthanum and nickel complexes with 4- 4b) were synthesized using lanthanum nitrate hexahydrate (La(NO 3 ).6H 2 O) and nickel dichloride hexahydrate (NiCl 2 .6H 2 O). The synthesized complexes 5a-d were isolated and characterized by IR, Mass, and 1 HNMR spectroscopy. The spectra of complexes 5a-d were interpreted on the basis of comparison with the spectrum of the free ligand. These complexes were screened for DNA photocleavage activity. Two complexes, 5a, and 5b, gave significantly good results found to degrade both forms of DNA (SC and NC). Our data give the reason to conclude that these compounds can act as lead compounds and should be submitted to further more detailed biological evaluation.

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Unraveling the effects of light rare-earth element (Lanthanum (III)) on the efficacy of partial-nitritation process and its responsible functional genera

Zhang

Antwi

et al. 2021

Chemical Engineering Journal

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Lanthanum(III) and neodymium(III) complexes with anti-inflammatory drug sulindac: Synthesis, characterization, thermal investigation using coupled techniques TG-FTIR, and in vitro biological studies

Cited by 8 publications

References 41 publications

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

Three novel spiral chain Nd (III) Eu (III) Sm (III)complexes bridged by 1,1 '(1,4‐phenylene‐bis [methylene])‐bis (pyridine‐3‐carboxylicaicd): Synthesis, structural characterization, and antitumor activity

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Unraveling the effects of light rare-earth element (Lanthanum (III)) on the efficacy of partial-nitritation process and its responsible functional genera

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