Laparoscopic Adrenalectomy for Removal of Unilateral Noninvasive Pheochromocytomas in 10 Dogs

Pitt, Kathryn A.; Mayhew, Philipp D.; Steffey, Michele A.; Culp, William T. N.; Fuller, Mark C.; Maggiore, Ann Della; Nelson, Richard W.

doi:10.1111/vsu.12552

Cited by 23 publications

(18 citation statements)

References 34 publications

(143 reference statements)

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“…The failure to mitigate hypertensive episodes with phenoxybenzamine pre-treatment was also demonstrated in several subsequent case series. 7,35,36 Breakthrough hypertension can still occur due to incomplete blockade with phenoxybenzamine and via release of other vasoconstrictive mediators such as neuropeptide Y. 37 To treat an intra-operative hypertensive crisis, the inhalational anaesthetic agent can be increased or acepromazine can be administered.…”

Section: Discussionmentioning

confidence: 99%

Short‐term outcome of adrenalectomy in dogs with adrenal gland tumours that did not receive pre‐operative medical management

et al. 2020

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Objective Review medical records of dogs that underwent adrenalectomy without pre‐operative medical management, to examine the peri‐operative morbidity and mortality. Design Case series of 65 dogs. Methods Medical records were reviewed. Features recorded included the histologic diagnosis, intra‐operative hypertension or tachycardia, requirement for cavotomy, administration of intra‐ and post‐operative corticosteroids, performance of additional surgery and the occurrence of peri‐operative complications. Dogs requiring emergency surgery were excluded. Results Of the 65 dogs, 49 had adrenocortical tumours (11 bilateral), 13 had pheochromocytomas (one bilateral) and three dogs had tumours in both adrenal glands of a different tumour type. Five dogs had caudal vena cava invasion and 33 had additional procedures performed at the same time. Mortality occurred in 1/65 dogs (1.5%; 95% CI 0.03%–8.2%), major complications were identified in 1/65 dogs (1.5%; 95% CI 0.03%–8.2%) and minor complications occurred in 10/53 dogs (15%; 95% CI 8.6%–26%). Conclusion Based on the limited peri‐operative complications and low mortality in this pre‐operatively untreated cohort, and based on critique of the available literature, the added value afforded by pre‐operative treatment is questioned. With appropriate management, adrenal tumours can be removed with few peri‐operative complications and low mortality.

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Section: Discussionmentioning

confidence: 99%

Short‐term outcome of adrenalectomy in dogs with adrenal gland tumours that did not receive pre‐operative medical management

et al. 2020

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“…Laparoscopic adrenalectomy has gained in popularity in veterinary medicine and observational studies have shown that it results in more rapid recovery, shorter hospitalization, fewer wound complications and shorter surgical time than open laparotomy , . The size of the PCC and the extent of vascular invasion are the most important criteria in choosing between laparoscopy and open laparotomy.…”

Section: Treatmentmentioning

confidence: 99%

Pheochromocytomas and paragangliomas in humans and dogs

Galac

Korpershoek

2017

Vet Comparative Oncology

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Pheochromocytomas (PCCs) and paragangliomas (PGLs) are described in several species. In humans and dogs they have many similarities: the excessive catecholamine release in hormonally active PCC causes similar clinical signs, the frequency of metastasis is similar, and they are histopathologically almost identical. Surgery is curative when PCC and PGL have not metastasized, while only palliative treatment is possible for patients with metastatic disease. Mutations in succinate dehydrogenase subunit B (SDHB) are associated with metastatic behaviour in human PCC/PGL and the same mutation has been described in dogs. The dog might therefore be a suitable model for study of the pathogenesis of metastatic PCC and PGL in humans. Further molecular studies of common tumourigenic pathways and comparative studies of histopathology of human and canine PCC and PGL are warranted.

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“…Classification of studies by organ system is presented in Tables S1 and S2. Numbers of studies and participants were reported within each organ/system group including female genital tract (22 studies [n = 1407 dogs]), 1,7,11,20,30‐47 urinary tract (7 studies [n = 114]), 3,48‐53 stomach (9 studies [n = 250]), 10,18,54‐59 intestinal tract (5 studies [n = 48]), 60‐64 liver (5 studies [n = 288]), 12,17,65‐67 adrenal gland (5 studies [n = 62]), 13,28,68‐70 spleen (7 studies [n = 111]), 19,71‐76 and other (4 studies that included gastropexy and ovariectomy procedures [n = 148]) 9,77‐79 . One experimental study, in which colopexy in seven male dogs was described, was classified as intestinal tract even though these dogs were also sterilized during the surgical procedure because this study reported only complications and outcomes related to colopexy 63 .…”

Section: Resultsmentioning

confidence: 99%

A systematic review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs

et al. 2020

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Objective To evaluate and report the quality of the scientific literature reporting complications associated with laparoscopic and laparoscopic‐assisted procedures in client‐owned or healthy research dogs and to report and illustrate laparoscopic complications related to individual organ systems. Study design Systematic review. Animals Client‐owned or healthy research dogs. Methods A literature review was performed by using PubMed and CAB abstracts for English‐language studies providing descriptions of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs. Study selection used PRISMA (Preferred Reporting Items for Systematic reviews and Meta‐Analyses) guidelines. Quality assessment was performed by using a MINORS (Methodological Items for Non‐Randomized Studies) scoring system and a grading scale of level of evidence. Descriptive statistics were used. Results In total, 741 manuscripts were identified, with 64 manuscripts eligible for data extraction and quality assessment. The most represented organ system was the female genital tract, represented by 22 (34.4%) studies. The most commonly reported intraoperative and postoperative complications were related to abdominal entry and portal incisions, respectively. In 53 of 54 non‐randomized studies, high risk of bias was found. Forty‐eight (75%) studies provided level III or IV evidence. Conclusion This report provides an updated review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs, classified by organ system. The overall quality of evidence was low, limiting direct comparison of complication rates between studies. Clinical significance There is a need for implementation of standardized criteria for defining complications, study time frames and greater numbers of high quality prospective randomized trials in veterinary laparoscopy to permit comparison of complication and conversion rates between published studies and across organ systems.

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Laparoscopic Adrenalectomy for Removal of Unilateral Noninvasive Pheochromocytomas in 10 Dogs

Abstract: With careful case selection, laparoscopic adrenalectomy for resection of pheochromocytoma was feasible and could be performed efficiently by experienced laparoscopic surgeons.

Cited by 23 publications

References 34 publications

Short‐term outcome of adrenalectomy in dogs with adrenal gland tumours that did not receive pre‐operative medical management

Short‐term outcome of adrenalectomy in dogs with adrenal gland tumours that did not receive pre‐operative medical management

Pheochromocytomas and paragangliomas in humans and dogs

A systematic review of complications related to laparoscopic and laparoscopic‐assisted procedures in dogs

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