The use of surgical drain after abdominal surgery has always been a controversial issue.Benefits and risks related to the operatively placed drains in the abdominal cavity have been discussed since a hundred years ago when some surgeons where in favor of the drainage, while skeptic others considered not physiological their use (1, 2).In the common practice intra-abdominal drains have been used to help the surgeons in the post-operative phase to identify post-operative bleeding, to drain and monitor residual intraperitoneal pathologic liquids (such as bile, fecal material, pancreatic juice), and in order to prevent intra-abdominal septic collections (3).So far, however, there is a lack of evidence proving significant benefits of surgical drains and, moreover, drains themselves have been imputed as responsible for related complications which may increase post-operative morbility (1,(4)(5)(6)(7)(8)(9)(10)(11)(12).Similarly, placement of drains after splenectomy has been largely debated. Theoretically, the use of drain in splenectomised patients, whose susceptibility to infections and sepsis due to some microbial agents is well known, might predispose to an increased risk of subphrenic abscess formation and systemic infections (13,14). This assertion, however, has been resized in other studies (15-17). The increased risk of loco-regional or systemic infections in drained patients following splenectomy, has been related to associated, not intra-operatively recognized, injuries to the pancreatic tail and/or to the bowel, or they have been ascribed to the drainage system itself (18).In this study, we report our experience in a large series of open and laparoscopic splenectomies where the left sub-phrenic drainage has been routinely used. We attempt to answer if in our experience drainage could have