Laparoscopic colon and rectal resections with intracorporeal anastomosis and trans-vaginal specimen extraction for colorectal cancer. A case series and systematic literature review

Stipa, F; Burza, Antonio; Curinga, R.; Santini, E.; Site, Pietro Delle; Avantifiori, Riccardo; Picchio, Marcello

doi:10.1007/s00384-015-2178-x

Cited by 10 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By reducing the length of the incision, IA provides superior cosmetic results to those of EA. Attempts have also been made to combine IA with specimen extraction through a natural orifice, extracting specimens via the vagina or rectum to minimize destruction of the abdominal wall and achieve less invasiveness and better cosmetic results in a concept different from that of reduced port surgery (22,23).…”

Section: Discussionmentioning

confidence: 99%

Short- and Long-term Outcomes of 2-Step Stapled Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Colectomy for Colon Cancer

et al. 2019

View full text Add to dashboard Cite

Background/Aim: Intracorporeal anastomosis (IA) in laparoscopic colectomy for colon cancer is technically difficult, and there is a lack of consensus on the risk of bacterial contamination and cancer cell dissemination. In this study, short-and long-term outcomes of IA were examined. Patients and Methods: Short and longterm outcomes of those who underwent IA (n=44) or extracorporeal anastomosis (EA) (n=61) were compared. Results: IA was better than EA for blood loss, incision length, and first stool. Maximum temperature and C-reactive protein on postoperative day 1 were higher for the IA group. The rate of positive cultures from intraoperative lavage was higher for IA. The rate of positive cultures improved to an equivalent level by replacing mechanical pretreatment with chemical pretreatment. IA and EA were equivalent for the results of ascites cytology from lavage. Conclusion: With the use of appropriate preoperative treatment, IA takes advantage of the minimally invasive nature of laparoscopic surgery.Extracorporeal functional end-to-end anastomosis (FEEA), in which the dissected and mobilized bowel is delivered outside the body and a linear stapler is used to form the anastomosis, is currently widely used in laparoscopic colectomy for colon cancer because of its safety and simplicity. However, in obese patients with thick abdominal walls or mesenteric fat tissue, or in patients who have cancer of the transverse or descending colon, or cancer of the proximal sigmoid colon for which the double stapling technique cannot be used for anastomosis, it may be difficult to adequately deliver the bowel outside the body for reasons such as obstruction of the small incision by the mesentery or because of insufficient bowel length. Although intracorporeal anastomosis (IA) resolves these issues, its technical difficulty and the lack of consensus on the risk of bacterial contamination, cancer cell dissemination, and its short-term and long-term postoperative outcomes mean that it is not generally performed. In this study, outcomes of the anastomotic method of IA for colon cancer were compared with those of conventional extracorporeal anastomosis (EA). The effectiveness of and problems with IA were evaluated by investigating its postoperative outcomes in both the short and long term, and bacterial contamination in terms of postoperative biological reactions and ascites bacterial cultures, as well as cancer cell dissemination from the results of ascites cytology. Patients and MethodsStudy design. The subjects of this study were patients with colon cancer who underwent laparoscopic surgery between April 2015 and December 2018. Patients who also underwent gastric, large bowel, small bowel, or gallbladder resection at the same time were excluded. These patients were then divided into those who first underwent lymph node dissection and bowel mobilization within the peritoneal cavity, after which EA was performed by delivering the bowel outside the body through the small incision and creating an FEEA with a linear stapler under di...

show abstract

Section: Discussionmentioning

confidence: 99%

Short- and Long-term Outcomes of 2-Step Stapled Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Colectomy for Colon Cancer

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Colon cancer is a common malignant digestive tract tumor, and usually occurs at the junction between the rectum and sigmoid colon ( 24 ). Systematic review has demonstrated that peritoneal carcinomatosis from colon cancer blocks cytoreduction and intraperitoneal chemotherapy, which requires further investigation ( 25 ).…”

Section: Discussionmentioning

confidence: 99%

Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway

Shang

Guan

2018

Mol Med Report

View full text Add to dashboard Cite

Epidemiology and evidence have demonstrated that colon carcinoma is one of the most common gastrointestinal tumors in the clinic. Reports have suggested that Tunicamycin significantly inhibits aggressiveness of colon carcinoma cells by promotion of apoptosis. In the present study, the inhibitory effect of tunicamycin on colon cancer cells and the potential underlying molecular mechanism was investigated. Western blotting, immunohistochemistry, apoptotic assays and immunofluorescence were used to analyze the therapeutic effects of tunicamycin on apoptosis, growth, aggressiveness and cell cycle of colon tumor cells, by downregulation of fibronectin, vimentin and E-cadherin expression levels. In vitro experiments demonstrated that tunicamycin significantly inhibited growth, migration and invasion of colon carcinoma cells. In addition, tunicamycin administration promoted apoptosis of colon carcinoma cells via upregulation of apoptotic protease activating factor 1 and cytochrome c expression levels, which are proteins that have a role in mitochondrial apoptosis signaling. Cell cycle assays revealed that tunicamycin suppressed proliferation and arrested S phase entry of colon carcinoma cells. Mechanistic analysis demonstrated that tunicamycin reduced expression and phosphorylation levels of extracellular signal-regulated kinase (ERK), c-JUN N-terminal kinase (JNK) and protein kinase B (AKT), and inhibited mammalian target of rapamycin (mTOR) expression levels in colon carcinoma cells. Endogenous overexpression of ERK inhibited tunicamycin-mediated downregulation of JNK, AKT and mTOR expression, which further blocked tunicamycin-mediated inhibition of growth and aggressiveness of colon carcinoma. In vivo assays revealed that tunicamycin treatment significantly inhibited tumor growth and promoted apoptosis, which led to long-term survival of tumor-bearing mice compared with the control group. In conclusion, these results suggested that tunicamycin may inhibit growth and aggressiveness of colon cancer via the ERK-JNK-mediated AKT/mTOR signaling pathway, and suggested that tunicamycin may be a potential anti-cancer agent for colon carcinoma therapy.

show abstract

International Guideline on Natural Orifice Specimen Extraction Surgery (NOSES) for Colorectal Cancer (2023 Version)

Liu,

Guan,

Zhang

et al. 2023

Natural Orifice Specimen Extraction Surgery

View full text Add to dashboard Cite

Laparoscopic colon and rectal resections with intracorporeal anastomosis and trans-vaginal specimen extraction for colorectal cancer. A case series and systematic literature review

Abstract: Our case series, according to the results of the literature, showed that intracorporeal anastomosis associated to trans-vaginal specimen extraction is feasible and safe in selected female patients.

Cited by 10 publications

References 45 publications

Short- and Long-term Outcomes of 2-Step Stapled Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Colectomy for Colon Cancer

Short- and Long-term Outcomes of 2-Step Stapled Intracorporeal Versus Extracorporeal Anastomosis in Laparoscopic Colectomy for Colon Cancer

Tunicamycin inhibits colon carcinoma growth and aggressiveness via modulation of the ERK-JNK-mediated AKT/mTOR signaling pathway

International Guideline on Natural Orifice Specimen Extraction Surgery (NOSES) for Colorectal Cancer (2023 Version)

Contact Info

Product

Resources

About