Laparoscopic Cryoablation of a Metastatic Carcinoid Tumor

Duperier, Terive; Ali, Amjad; Pereira, Stephen G.; Davies, Richard J.; Ballantyne, Garth H.

doi:10.1089/109264201750162419

Cited by 12 publications

(4 citation statements)

References 22 publications

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“…During freeze/thaw cycles, intracellular and extracellular ice formation occurs in an area termed ‘the iceball’ leading to tumor destruction. Hepatic cryotherapy at laparotomy or laporoscopy surgery for patients with endocrine metastases has been used for a number of years [36, 37, 38, 39, 40, 41, 42]and has demonstrated successful results in terms of symptom control and objective tumor responses [37, 40, 41]. Cryotherapy is a supplement to surgical resection and allows regional destruction of lesions not amenable to resection.…”

Section: Radiofrequency Ablation and Cryotherapymentioning

confidence: 99%

Ablative Therapies for Liver Metastases of Gastroenteropancreatic Endocrine Tumors

Ruszniewski

O’Toole²

2004

Neuroendocrinology

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Hepatic metastases are frequent in patients with gastroenteropancreatic (GEP) endocrine tumors. The presence of hepatic metastases affects overall prognosis and quality of life especially in the presence of debilitating functional syndromes. Surgery, although the method of choice for hepatic metastases, is usually impossible due to disease extent. Results of systemic chemotherapy are also disappointing especially in patients with metastases from midgut GEP tumors. These latter patients usually have carcinoid syndrome which can be controlled by somatostatin analogues. Other therapeutic options in the treatment of highly vascular liver metastases from GEP tumors are locoregional strategies by inducing vascular occlusion resulting in ischemia and necrosis of tumoral tissue. Surgical ligation of the hepatic artery or transient hepatic ischemia has been replaced by transcatheter arterial chemoembolization (TACE). TACE has proven effective in controlling symptoms and gives objective tumor response in about half of patients. Other regional destructive methods, used either alone or in combination with surgery, include radiofrequency ablation and cryotherapy. The latter strategies are poorly evaluated to date and are usually adjuncts to surgery and reserved for limited disease.

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Section: Radiofrequency Ablation and Cryotherapymentioning

confidence: 99%

Ablative Therapies for Liver Metastases of Gastroenteropancreatic Endocrine Tumors

Ruszniewski

O’Toole²

2004

Neuroendocrinology

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“…During freeze/thaw cycles, intracellular and extracellular ice formation occurs in an area termed 'the iceball' leading to tumor destruction. Use of hepatic cryotherapy at laparotomy or laporoscopy surgery for patients with endocrine metastases has been used for a number of years (Cozzi et al 1995, Shafir et al 1996, Shapiro et al 1998, Seifert et al 1998, Duperier et al 2001, Sheen et al 2002, Tait et al 2002 and has demonstrated successful results in terms of symptom control and objective tumor responses (Cozzi et al 1995, Shapiro et al 1998, Seifert et al 1998. Cryotherapy is an important supplement to surgical resection and allows regional destruction to lesions not amenable to resection.…”

Section: Cryotherapymentioning

confidence: 99%

Ablative therapies for liver metastases of digestive endocrine tumours.

O’Toole¹,

Maire²,

Ruszniewski³

2003

Endocrine-Related Cancer

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Hepatic metastases are frequently encountered in patients with digestive endocrine tumors and their presence plays an important role in quality of life and overall prognosis. Surgery is the treatment method of choice for hepatic metastases but this is frequently impossible due to the extent of disease. Systemic chemotherapy is offered to patients with diffuse and/or progressive liver metastases but results are disappointing especially in patients with metastases of midgut origin. In the latter patients with carcinoid syndrome, somatostatin analogs are frequently initially effective but their efficacy wanes due to disease progression and development of tachyphylaxis. Other therapeutic options in the treatment of hepatic metastases are locoregional strategies where vascular occlusion induces ischemia in these highly vascular tumors using either surgical or radiological techniques. Available methods include surgical ligation of the hepatic artery, transient hepatic ischemia or sequential hepatic arterialization. Trans-catheter arterial chemoembolization has proven effective in terms of long palliation and objective tumor responses. Other treatments aimed at regional destruction either alone or in combination with surgery include radiofrequency ablation and cryotherapy. The latter are usually important adjuncts to surgery and are usually reserved for limited disease.

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“…Cryoablation involves freezing and thawing of tumors, resulting in tumor ablation. [55][56][57][58][59] Cryotherapy can be used percutaneously or intraoperatively using intraoperative ultrasound and probes, and has become an important adjunct to surgical cytoreduction. Drawbacks include the large size of the probe, which causes increased risk for hemorrhage and higher rates of complications for larger metastases.…”

Section: Cryoablationmentioning

confidence: 99%

Role of Interventional Radiology in the Treatment of Patients with Neuroendocrine Metastases in the Liver

Kvols¹,

Turaga²,

Strosberg³

et al. 2009

J Natl Compr Canc Netw

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Management of liver metastasis from neuroendocrine tumors routinely includes an interventional radiologist. Hepatic artery embolization, either bland (transarterial embolization) or with chemotherapy (transarterial chemoembolization), has been shown to improve response rates in neuroendocrine metastases to the liver. Radiofrequency ablation, cryotherapy, and percutaneous alcohol ablation are important adjuncts or alternative treatments to surgical debulking. In this article, the authors examine important techniques in the armamentarium of the interventional radiologist.

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Laparoscopic Cryoablation of a Metastatic Carcinoid Tumor

Cited by 12 publications

References 22 publications

Ablative Therapies for Liver Metastases of Gastroenteropancreatic Endocrine Tumors

Ablative Therapies for Liver Metastases of Gastroenteropancreatic Endocrine Tumors

Ablative therapies for liver metastases of digestive endocrine tumours.

Role of Interventional Radiology in the Treatment of Patients with Neuroendocrine Metastases in the Liver

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