Laparoscopic excision of bilateral primary adrenal leiomyosarcomas in a 14-year-old girl with acquired immunodeficiency syndrome (AIDS)

Linos, Dimitrios; Kiriakopoulos, Andreas; Tsakayannis, Dimitrios; Theodoridou, Maria; Chrousos, George P.

doi:10.1016/j.surg.2003.07.007

Cited by 21 publications

(34 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Most of the tumors have been unilateral; only 2 patients had bilateral tumors. 12,17 Tumors were larger than 8 cm in diameter in 63.2% of cases; there have only been a few cases where the tumors were 3 cm and presented as a mass in the abdomen or flank. 14 There are no tumor markers or imaging characteristics that allow a preoperative diagnosis, and all cases have been diagnosed after surgical resection or at necropsy.…”

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Leiomyosarcoma

et al. 2014

View full text Add to dashboard Cite

Primary adrenal leiomyosarcoma is a very rare tumor with an unusual location; the diagnosis is based entirely on histological and immunohistochemical evaluations. We report a primary adrenal leiomyosarcoma in a 57-year-old woman who was incidentally found to have an adrenal-occupying lesion during a routine medical examination. Computed tomography revealed a 64 mm × 77 mm soft tissue mass in the left adrenal gland. The patient underwent left radical nephroadrenalectomy. Histological examination of the tumor showed malignant spindle cells in interlacing fasicles and whorls. Nuclear pleomorphism, tumor giant cells, necrosis, and abnormal mitotic figures were present. On immunohistochemistry, the tumor cells were strongly positive for smooth muscle actin, desmin, and vimentin expression, but negative for cytokeratin, CD117, CD34, CD68, Myoglobin, S100, and HMB-45.The final histopathological diagnosis was primary adrenal leiomyosarcoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Leiomyosarcoma

et al. 2014

View full text Add to dashboard Cite

show abstract

“…1 In the present patient, it was not known whether the bilateral tumors were each primary or whether the right one had metastasized to the left adrenal gland. The present case was an unusual one in that the patient presented with LMSs in both adrenal glands and without evident distant metastasis.…”

Section: Discussionmentioning

confidence: 66%

“…2,6-10 In one of these six patients (case 11), bilateral laparoscopic adrenalectomy was performed in relatively small ALMS. 1 None of the six patients who had no recurrence underwent any adjuvant therapy such as chemother- Fig. 2.…”

Section: Discussionmentioning

confidence: 98%

“…1 In that case, the patient, with HIV, had simultaneous bilateral ALMS 5 years after the resection of a left ALMS. Several ALMSs have occurred in patients with HIV.…”

Section: Introductionmentioning

confidence: 95%

“…Several ALMSs have occurred in patients with HIV. [1][2][3] Radical resection is reportedly the only effective therapy, and in the advanced stages the prognosis is extremely poor even if patients have received adjuvant therapies such as chemotherapy and radiotherapy. 4,5 We herein report a patient who had simultaneous bilateral ALMS, distant metastases at multiple sites after the resection of the right ALMS, and underwent multiple local therapies, including operations, radiotherapy, and radiofrequency ablation (RFA).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bilateral adrenal leiomyosarcoma treated with multiple local therapies

et al. 2009

View full text Add to dashboard Cite

A 62-year-old woman presented with right flank pain, and computed tomography (CT) showed bilateral adrenal tumors (right, 8 cm; left, 4 cm). There were no abnormal findings on physical examination, and adrenal hormone levels in serum and urine were within normal limits. Radiological studies showed a right adrenal tumor with intratumoral hemorrhage, a cystic tumor in the left adrenal gland, and no sign of distant metastasis. Because laboratory tests showed normal levels of adrenal hormones, we considered the tumors to be nonfunctioning adrenal tumors. The right adrenal tumor was surgically removed because it was thought to be malignant, and histological examination revealed that it was a leiomyosarcoma. Postoperative CT showed a pleural metastasis in the right chest wall. The patient received combination chemotherapy with cyclophosphamide, vincristine, adriamycin, and dacarbazine. The metastasis was also treated with radiofrequency ablation (RFA). Because the left adrenal tumor grew rapidly despite two courses of the chemotherapy, it too was surgically removed. After the operation, metastasis in the right iliac bone was treated with RFA and radiotherapy. Positron emission tomography detected bilateral femoral metastases, and these were treated with radiotherapy in combination with a low dose of cisplatin. A liver metastasis and a small metastasis in the left kidney were treated with RFA and a metastasis in the pancreatic tail was removed surgically. Sixteen months after the right adrenalectomy, the patient died due to systemic spread of the disease. Multiple local treatments including RFA, radiotherapy, and resection were effective for the local control of metastatic lesions of adrenal leiomyosarcoma.

show abstract

Adrenal Embryology and Pathology

Mangray

DeLellis

2008

Adrenal Imaging

View full text Add to dashboard Cite

Laparoscopic excision of bilateral primary adrenal leiomyosarcomas in a 14-year-old girl with acquired immunodeficiency syndrome (AIDS)

Cited by 21 publications

References 3 publications

Primary Adrenal Leiomyosarcoma

Primary Adrenal Leiomyosarcoma

Bilateral adrenal leiomyosarcoma treated with multiple local therapies

Adrenal Embryology and Pathology

Contact Info

Product

Resources

About