Laparoscopic Fundoplication in Patients with a Hypertensive Lower Esophageal Sphincter

Lamb, Peter; Myers, Jennifer C.; Thompson, Sarah K.; Jamieson, Glyn G.

doi:10.1007/s11605-008-0688-3

Cited by 5 publications

(2 citation statements)

References 14 publications

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“…The main evidence for hypertensive LES being secondary to acid reflux is the fact that following a Nissen fundoplication sphincter pressure, and pH-metry, values get in the normal range again and reflux symptoms disappear. 18 , 19 A further protective mechanism to reduce excessive acid exposure of the esophagus is the development of a lower esophageal or Schatzki’s ring. GERD has been reported to be present in 31%–60% of the cases, with hiatal hernia reported to be a cofinding in all patients with Schatzki’s ring.…”

Section: Discussionmentioning

confidence: 99%

Achalasia following reflux disease: coincidence, consequence, or accommodation? An experience-based literature review

Vereczkei

Bognár

Papp

et al. 2017

TCRM

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Achalasia is a motility disorder of the esophagus characterized by the defective peristaltic activity of the esophageal body and impaired relaxation of the lower esophageal sphincter due to the degeneration of the inhibitory neurons in the myenteric plexus of the esophageal wall. The histopathological and pathophysiological changes in achalasia have been well described. However, the exact etiological factors leading to the disease still remain unclear. Currently, achalasia is believed to be a multifactorial disease, involving both extrinsic and intrinsic factors. Based on our experience and the review of literature, we believe that gastroesophageal reflux disease (GERD) might be one of the triggering factors leading to the development of achalasia. However, it is also stated that the two diseases can simultaneously appear independently from each other. Considering the large number and routine treatment of patients with GERD and achalasia, the rare combination of the two may even remain unnoticed; thus, the analysis of larger patient groups with this entity is not feasible. In this context, we report four cases where long-standing reflux symptoms preceded the development of achalasia. A literature review of the available data is also given. We hypothesize that achalasia following the chronic acid exposure of the esophagus is not accidental but either a consequence of a chronic inflammation or a protective reaction of the organism in order to prevent aspiration and lessen reflux-related symptoms. This hypothesis awaits further clinical confirmation.

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Section: Discussionmentioning

confidence: 99%

Achalasia following reflux disease: coincidence, consequence, or accommodation? An experience-based literature review

Vereczkei

Bognár

Papp

et al. 2017

TCRM

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“…A standard definition of heartburn was used as any subjective pain or burning sensation in the retro‐sternal area. Subjective scoring was tabulated every minute on a scale of 1–10, with 10 as the intolerable pain/burning 9 . To prevent additive effects of acid on heartburn, the varying acid concentrations were infused in a random manner.…”

Section: Methodsmentioning

confidence: 99%

Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagus

Dutta

Agrawal

Mahʼmoud

2010

Aliment Pharmacol Ther

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Gastroesophageal Reflux Disease Might Induce Certain—Supposedly Adaptive—Changes in the Esophagus: A Hypothesis

et al. 2018

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Laparoscopic Fundoplication in Patients with a Hypertensive Lower Esophageal Sphincter

Abstract: Laparoscopic fundoplication can be performed with good long-term results for patients with reflux and a hypertensive LES. However, those with preoperative dysphagia have a higher failure rate.

Cited by 5 publications

References 14 publications

Achalasia following reflux disease: coincidence, consequence, or accommodation? An experience-based literature review

Achalasia following reflux disease: coincidence, consequence, or accommodation? An experience-based literature review

Modulation of salivation and heartburn in response to the site of acid infusion in the human oesophagus

Gastroesophageal Reflux Disease Might Induce Certain—Supposedly Adaptive—Changes in the Esophagus: A Hypothesis

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