Laparoscopic Greater Curvature Plication in Morbidly Obese Women with Type 2 Diabetes: Effects on Glucose Homeostasis, Postprandial Triglyceridemia and Selected Gut Hormones

Bradnova, Olga; Kyrou, Ioannis; Hainer, Vojtěch; Včelák, Josef; Halkova, Tereza; Šrámková, Petra; Dolezalová, K; Fried, Martin; McTernan, P. G.; Kumar, Sudhesh; Hill, Martin; Kunešová, Marie; Bendlová, Běla; Vrbíková, Jana

doi:10.1007/s11695-013-1143-4

Cited by 41 publications

(33 citation statements)

References 38 publications

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“…After LGP, ghrelin levels decrease while GIP levels increase. 33 This is likely due to infolding of the highly vascular fundus, which may result in decreased perfusion and ghrelin hyposecretion. Increased GIP levels may be due to accelerated gastric emptying and/or contact with less well-digested chime.…”

Section: Gastric Endoscopic Proceduresmentioning

confidence: 99%

Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action

Jirapinyo

Thompson

2017

Clinical Gastroenterology and Hepatology

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Obesity is a worsening pandemic with numerous related comorbid illnesses. Conservative management including lifestyle modification and medications have limited efficacy. In contradistinction, bariatric surgery is effective, however, with substantial cost and non-negligible morbidity and mortality. As such, a small percentage of eligible patients undergo surgery. Over the past decade, endoscopic bariatric therapies (EBTs) have been introduced as a less invasive option for the treatment of obesity and its related comorbid illnesses. This paper reviews major endoscopic bariatric therapies, their surgical analogues and proposed mechanisms of action. Clinical trial data for each device are also discussed.

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Section: Gastric Endoscopic Proceduresmentioning

confidence: 99%

Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action

Jirapinyo

Thompson

2017

Clinical Gastroenterology and Hepatology

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“…Restrictive procedures such as vertical gastrectomy favor changes in the incretin system, possibly through vagal afferent manipulation as this technique does not favor the early exposition of the distal gut, like other techniques (bypass, biliopancreatic derivation) [69]. Procedures involving no resection, such as gastric plication have demonstrated to favor weight loss with an improved glycemic control and an elevated GIP, without changing GLP-1 concentrations, which suggest that the mechanic event of afferent pathway dissension isn't enough to alter GLP-1 kinetics, explaining its positive effects on diabetes and AD.…”

Section: Surgery For Diabetes Controls An Alzheimer's Disease?mentioning

confidence: 99%

Untitled

2017

EMIJ

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“…Another recent surgical procedure is the laparoscopic greater gastric curvature plication (LGCP). It is a procedure that reduces the gastric volume using sutures that invaginates the greater curvature, avoiding stapling or gastric resection, and aiming to reduce morbidity and costs for obesity surgery 6 , 7 . Although with good excess weight loss in clinical series, it still causes perioperative morbidity due to the gastric devascularisation without gastric resection.…”

Section: Introductionmentioning

confidence: 99%

New Technique for Obesity Surgery: Internal Gastric Plication Technique Using Intragastric Single-Port (Igs-Igp) in Experimental Model

Müller

Fikatas

Gül

et al. 2017

ABCD, arq. bras. cir. dig.

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Background: Bariatric surgery is currently the most effective method to ameliorate co-morbidities as consequence of morbidly obese patients with BMI over 35 kg/m2. Endoscopic techniques have been developed to treat patients with mild obesity and ameliorate comorbidities, but endoscopic skills are needed, beside the costs of the devices. Aim:To report a new technique for internal gastric plication using an intragastric single port device in an experimental swine model. Methods: Twenty experiments using fresh pig cadaver stomachs in a laparoscopic trainer were performed. The procedure was performed as follow in ten pigs: 1) volume measure; 2) insufflation of the stomach with CO2; 3) extroversion of the stomach through the simulator and installation of the single port device (Gelpoint Applied Mini) through a gastrotomy close to the pylorus; 4) performance of four intragastric handsewn 4-point sutures with Prolene 2-0, from the gastric fundus to the antrum; 5) after the performance, the residual volume was measured. Sleeve gastrectomy was also performed in further ten pigs and pre- and post-procedure gastric volume were measured. Results: The internal gastric plication technique was performed successfully in the ten swine experiments. The mean procedure time was 27±4 min. It produced a reduction of gastric volume of a mean of 51%, and sleeve gastrectomy, a mean of 90% in this swine model. Conclusion: The internal gastric plication technique using an intragastric single port device required few skills to perform, had low operative time and achieved good reduction (51%) of gastric volume in an in vitro experimental model.

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Laparoscopic Greater Curvature Plication in Morbidly Obese Women with Type 2 Diabetes: Effects on Glucose Homeostasis, Postprandial Triglyceridemia and Selected Gut Hormones

Abstract: During the initial 6-month postoperative period, LGCP induces significant weight loss and improves the metabolic profile of morbidly obese T2DM patients, while it also decreases circulating postprandial ghrelin levels and increases the meal-induced GIP response.

Cited by 41 publications

References 38 publications

Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action

Endoscopic Bariatric and Metabolic Therapies: Surgical Analogues and Mechanisms of Action

Untitled

New Technique for Obesity Surgery: Internal Gastric Plication Technique Using Intragastric Single-Port (Igs-Igp) in Experimental Model

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