Laparoscopic Microwave
Thermotherapy on Small Renal Tumors:
Experimental Studies Using Implanted
VX-2 Tumors in Rabbits

Kigure, Teruaki; Harada, Takeshi; Yuri, Yasuhiro; Satoh, Yuji; Yoshida, Kanji

doi:10.1159/000474199

Cited by 30 publications

(9 citation statements)

References 7 publications

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“…Experimental studies in rabbits have suggested oncological equivalence with nephrectomy [49]. The disadvantages of the limited zone of ablation and the large antenna size have limited the minimally invasive application of microwave thermotherapy.…”

Section: Microwave Thermotherapymentioning

confidence: 99%

The Management of Small Renal Tumours by Ablative Therapies

Sriprasad¹,

Marsh²

2011

Current Cancer Treatment - Novel Beyond Conventional Approaches

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Section: Microwave Thermotherapymentioning

confidence: 99%

The Management of Small Renal Tumours by Ablative Therapies

Sriprasad¹,

Marsh²

2011

Current Cancer Treatment - Novel Beyond Conventional Approaches

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“…62 For surgical therapy, the microwaves are emitted from a flexible antenna. Microwave energy can be used for coagulation as well as ablation; it has been employed for hemostasis in open 63 and laparoscopic [64][65][66][67] partial nephrectomies. The flexibility of the microwave antenna and the coagulative nature of thermotherapy make the approach ideal for renal ablation.…”

Section: Microwave Thermotherapymentioning

confidence: 99%

“…Kigure and associates reported on the laparoscopic application of MT in an in vivo VX-2 tumor model implanted in rabbit kidneys (Table 4). 67 Their report showed no difference in survival between rabbits treated with laparoscopic MT and those undergoing open nephrectomy. The initial studies demonstrated the ability of MT to cause coagulative necrosis 5 mm from the electrode; temperatures .60°C were routinely recorded.…”

mentioning

confidence: 95%

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Needle-Based Ablation of Renal Parenchyma Using Microwave, Cryoablation, Impedance- and Temperature-Based Monopolar and Bipolar Radiofrequency, and Liquid and Gel Chemoablation: Laboratory Studies and Review of the Literature

Rehman

Landman

Lee

et al. 2004

Journal of Endourology

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"Needle-based ablation of renal parenchyma using microwave, cryoablation, impedance-and temperature-based monopolar and bipolar radiofrequency, and liquid and gel chemoablation: Laboratory studies and review of the literature." Journal of Endourology.18,1. 83-104. (2004 ABSTRACTBackground and Purpose: Small renal tumors are often serendipitously detected during the screening of patients for renal or other disease entities. Rather than perform a radical or partial nephrectomy for these diminutive lesions, several centers have begun to explore a variety of ablative energy sources that could be applied directly via a percutaneously placed needle-like probe. To evaluate the utility of such treatment for small renal tumors/masses, we compared the feasibility, regularity (consistency in size and shape), and reproducibility of necrosis produced in normal porcine kidneys by different modes of tissue ablation: microwaves, cold impedance-based and temperature-based radiofrequency (RF) energy (monopolar and bipolar), and chemical. Chemoablation was accomplished using ethanol gel, hypertonic saline gel, and acetic acid gel either alone or with simultaneous application of monopolar or bipolar RF energy. Materials and Methods: A total of 107 renal lesions were created laparoscopically in 33 domestic pigs. Microwave thermoablation (N 5 12) was done using a Targis T3 (Urologix) 10F antenna. Cryoablation (N 5 16) was done using a single 1.5-mm probe or three 17F microprobes (17F SeedNet™ system; Galil Medical) (N 5 10 single probe and N 5 6 three probes); a double freeze cycle with a passive thaw was employed under ultrasound guidance. Dry RF lesions were created using custom-made 18-gauge single-needle monopolar probe with two or three exposed metal tips (GelTx) (N 5 12) or a single-needle bipolar probe (N 5 6) at 50 W of 510 kHz RF energy for 5 minutes. In addition, a multitine RF probe (RITA Medical Systems) was used in one set of studies (N 5 6). Both impedance-and temperature-based RF were evaluated. Chemoablation was performed with 95% ethanol (4 mL), 24% hypertonic saline (4 mL), and 50% acetic acid (4 mL) as single injections. In addition, chemoablation was tested with monopolar and bipolar RF (wet RF). Tissues were harvested 1 week after ablation for light microscopy.Results: In 11 of the 15 ablation techniques, there was complete necrosis in all lesions; however, three ethanol gel lesions had skip areas, three hypertonic saline gel lesions showed no necrosis or injury, and one monopolar RF and one bipolar RF lesion showed skip areas. In contrast to impedance-based RF, heat-based RF (RITA) caused complete necrosis without skip areas. All cryolesions resulted in complete tissue necrosis, and cryotherapy was the only modality for which lesion size could be effectively monitored using ultrasound imaging.

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“…The probes are placed directly into the target tissue. For the treatment of kidney tumors, only few experimental data exist (70).…”

Section: Miscellaneous Techniques Microwave Thermotherapymentioning

confidence: 99%