Laparoscopic microwave tissue ablation of hepatic metastasis from a parathyroid carcinoma

Ahmad, Fatima; Strickland, Andrew; Wright, Garnett; Elabassy, Mosheir; Kiruparan, Pasupathy; Bell, P. R. F.; Lloyd, David M.

doi:10.1016/j.ejso.2004.12.006

Cited by 9 publications

(4 citation statements)

References 5 publications

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“…However, ultrasound-guided biopsy of liver lesions played a role, and two of four cases were clearly diagnosed as metastases ( 10 – 12 ). Ultrasound guidance was used in three patients who received RFA or microwave ablation, and liver lesions that were difficult to find during surgery could also be located by intraoperative ultrasound scanning ( 11 , 13 ).…”

Section: Discussionmentioning

confidence: 99%

“…The case reported by Artinyan ( 10 ) was treated with combined RFA and TAE because of widespread liver metastases, and the patient was followed up for 4 months and showed normal PTH and serum calcium levels. Ahmad reported another case of S4a liver metastasis treated by laparoscopic microwave tissue ablation and achieved at least 15 months of survival ( 13 ). A few published studies have pointed out the possible benefits of RFA in the treatment of distant metastases, and some patients survive for up to 17 years with a combination of several RFA medical treatments ( 10 , 43 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

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Diagnosis and treatment of liver metastases of parathyroid carcinoma

Zhang²,

Yang³

et al. 2022

Front. Endocrinol.

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IntroductionParathyroid carcinoma (PC) is a very rare endocrine malignancy occurring in less than 1% of all cases of primary hyperparathyroidism (pHPT). The liver is the second most common target organ for distant metastases of PC, but no guidelines are available for the diagnosis and treatment of liver metastases. In this study, we attempted to summarize the characteristics of the diagnosis and treatment of liver metastases based on our patients and other cases reported in the literature.Materials and methodsThe files of all patients diagnosed with PC with liver metastases summarized at our center between 2000 and 2022 were reviewed, and three datasets from Medline, Web of Science, and Embase were systematically searched to identify relevant articles.ResultsThree patients with liver metastases from our center and 11 patients from the literature were included in the study. All patients had pHPT with borderline remission of hypercalcemia after each operation. A total of 71.4% of the patients’ liver lesions were found by abdominal CT scans, while 35.7% were found by MRI, PET-CT, and fine-needle aspiration biopsy (FNAB), which were also helpful for diagnosis. Eight of nine patients (88.9%) who underwent surgery, radiofrequency ablation (RFA), or transcatheter arterial embolization (TAE) were alive, and only one postoperative patient died after a follow-up of 60 months.ConclusionsPC is a rare malignant tumor prone to recurrence and metastasis, and postoperative reviews should be carried out routinely. Abnormally elevated parathyroid hormone (PTH) and serum calcium can indicate recurrence or metastasis. Enhanced CT and MRI can provide valuable support for the diagnosis of liver metastases, but whether [18F]FDG-PET-CT, [18F]FCH-PET-CT, or [11C]choline-PET-CT can be used as a diagnostic basis requires further study. Resection of liver metastases, segmental hepatectomy, or RFA can significantly improve patients’ symptoms.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnosis and treatment of liver metastases of parathyroid carcinoma

Zhang²,

Yang³

et al. 2022

Front. Endocrinol.

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“…Treatment of isolated hepatic metastases from parathyroid carcinoma with the use of microwave tissue ablation, has recently been reported by Ahmad et al A 42‐year‐old woman initially treated for primary hyperparathyroidism (HPT) by parathyroidectomy experienced persistent hypercalcemia. She was diagnosed, by gadolinium‐enhanced magnetic resonance imaging (MRI) of the liver, with a solitary 4.5‐cm subcapsular lesion in segment IV‐A, which was confirmed by biopsy to be consistent with parathyroid carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: an unusual indication for hepatic resection

Mezhir

Melis

Headley

et al. 2007

J Hepatobiliary Pancreat Surg

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Primary carcinoma of the parathyroid gland is a rare disease. It is often diagnosed after recurrence of hyperparathyroidism following resection for presumed adenomatous disease. Local and distant recurrence is high and aggressive resection is advocated. Patients with parathyroid cancer are frequently plagued by severe hypercalcemia, which is often refractory to medical therapy. Herein we describe the case of a patient with metastatic parathyroid cancer localized to the liver. The patient was treated with a palliative hepatic resection for the management of persistent and refractory hypercalcemia. Intraoperative parathyroid hormone levels were utilized as an adjunct to determine successful metastatectomy. Our case highlights the importance of an aggressive approach to patients with metastatic parathyroid cancer, as well as the utility of intraoperative parathyroid hormone levels to confirm successful extirpation of disease.

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“…Microwave ablation of tumors within the liver may become an adjunct or alternative to resection in patients with primary or secondary (metastatic) cancers. This technique combines the benefits of a large, localized coagulative effect with a single insertion of the applicator, in a significantly shorter time than comparable treatments (3)(4)(5). Tumors as large as 6 cm have been successfully treated at high power and short times (150 W at 4 minutes) with 2.45 GHz microwaves.…”

Section: Introductionmentioning

confidence: 95%

A tutorial on recent advances in thermal therapy systems

Ryan¹

2007

Thermal Treatment of Tissue: Energy Delivery and Assessment IV

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Thermal therapy as a treatment for cancer is a dynamic treatment epicenter, with a variety of technologies available and undergoing continuous improvement. Recent advances in technology and applications for thermal therapy give clinicians more power to affect larger volumes of tissue in less time. New radiofrequency (RF) and microwave (MW) systems have appeared recently, giving powerful tools for cancer therapy. Novel therapeutic ultrasound (US) technologies are being explored, but are presently not commercialized. Thermal therapy applicators that deliver power to the target in the patient will be reviewed for shape, size, and features. The operation and performance of various applicators will be discussed. In the goal of performance increase, several features have been commercialized in the evolution of the technology, including cooling, multiple applicator arrays, power modulation, and applicator deployment and shape change. To place recent progress into perspective, a historical review of some RF and MW applicators will be given. The work will cover modeling and simulations, as well as in-vitro, in-vivo, and clinical results.

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Laparoscopic microwave tissue ablation of hepatic metastasis from a parathyroid carcinoma

Cited by 9 publications

References 5 publications

Diagnosis and treatment of liver metastases of parathyroid carcinoma

Diagnosis and treatment of liver metastases of parathyroid carcinoma

Successful palliation of hypercalcemia secondary to metastatic parathyroid cancer: an unusual indication for hepatic resection

A tutorial on recent advances in thermal therapy systems

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