Transversus abdominis plane (TAP) block technique seems to off er one of the most effi cient methods for a local pain control. Our aim is to demonstrate the eff ectiveness and safety of TAP block for post-operative pain control under laparoscopic vision in elderly patients during laparoscopic cholecystectomy. Th e patients aged more than 65 years old, who had cholecystectomy due to symptomatic cholelithiasis, were retrospectively evaluated. Th e patients that were operated under general anesthesia + laparoscopic TAP block and those who were operated only under only general anesthesia were compared according to their' age and gender, comorbidities, American Society of Anesthesiologists scores, visual analog scale (VAS) for pain and length of stay in the hospital. Median (±interquartile range) values of post-operative 24 th -hour-VAS for pain was found consecutively 2 (±1-3) in TAP block + group and 3 (±2-5) in TAP block -group. Th e median post-operative 24 th -hour-VAS value in overall patients was three. Patients' VAS values were higher in the TAP block -group with a statistically signifi cant diff erence (p = 0.001). Furthermore, no statistically signifi cant diff erence was found for other parameters in two groups. Th e laparoscopic-guided TAP block can easily be performed and has potential for lower visceral injury risk and shorter operational time. Effi cacy, safety and other advantages (analgesic requirements, etc.) make it an ideal abdominal fi eld block in elderly patients.