Laparoscopic Resection of a Retroperitoneal Bronchogenic Cyst—A Case Report—

Tanaka, Genki; Hara, Ryota; Yamashita, Hironari; Yasui, Akihiro; Suka, Yusuke; Nagai, Masaya; Ohira, Yasuyuki; Suzuki, Yoshio

doi:10.3919/jjsa.81.367

Cited by 1 publication

(2 citation statements)

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“…Bronchogenic cysts are congenital cysts that are established by persistent secretion from abnormal sprouting lung buds that lack continuity with the tracheobronchial system during fetal life[ 4 , 5 ]. Most bronchogenic cysts develop in the lungs or mediastinum; if abnormal lung buds sprout before 4 wk of fetal life, bronchogenic cysts are located in the mediastinum, and if they sprout after 4 wk of fetal life, bronchogenic cysts are located in the lungs[ 6 , 7 ]. The thoracic cavity and abdominal cavity are connected by the pericardioperitoneal canal, but they become separated by the diaphragm, which develops from the septum transversum, dorsal esophageal mesentery, and pleuroperitoneal fold by 7 wk of fetal life[ 6 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Most bronchogenic cysts develop in the lungs or mediastinum; if abnormal lung buds sprout before 4 wk of fetal life, bronchogenic cysts are located in the mediastinum, and if they sprout after 4 wk of fetal life, bronchogenic cysts are located in the lungs[ 6 , 7 ]. The thoracic cavity and abdominal cavity are connected by the pericardioperitoneal canal, but they become separated by the diaphragm, which develops from the septum transversum, dorsal esophageal mesentery, and pleuroperitoneal fold by 7 wk of fetal life[ 6 , 8 , 9 ]. Therefore, intra-abdominal bronchogenic cysts are considered to be caused by abnormally sprouted lung buds that wandered into the abdominal cavity prior to diaphragmatic formation through the pericardioperitoneal canal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intra-abdominal ectopic bronchogenic cyst with a mucinous neoplasm harboring a GNAS mutation: A case report

Murakami¹,

Shimizu²,

Yamazaki³

et al. 2022

WJCC

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BACKGROUND Bronchogenic cysts are congenital cysts caused by abnormal sprouting from the ventral foregut during fetal life. They usually occur in the mediastinum or lung, but there are very rare cases of ectopic bronchogenic cysts that develop in the abdominal cavity. A unique intra-abdominal ectopic bronchogenic cyst with a mucinous neoplasm that was producing carcinoembryonic antigen (CEA), harboring a GNAS mutation, is reported. The present case may contribute to clarifying the mechanism of tumorigenesis and malignant transformation of ectopic bronchogenic cysts. CASE SUMMARY In 2007, a man in his 50s was incidentally found to have an intra-abdominal cystic mass, 8 cm in diameter. Surgical resection was recommended, but he preferred to remain under observation. In 2020, his serum CEA level increased to 26.7 ng/mL, and abdominal computed tomography showed a 15 cm × 12 cm, multifocal, cystic mass located predominantly on the lesser curvature of the stomach. Since malignancy could not be ruled out, he finally underwent surgical resection. Histologically, the cystic wall was lined by ciliated columnar epithelium, accompanied by bronchial gland-like tissue, bronchial cartilage, and smooth muscle. Part of the cyst consisted of atypical columnar epithelium with an MIB-1 index of 5% and positive for CEA. Moreover, a GNAS mutation (p.R201C) was detected in the atypical epithelium, leading to a diagnosis of an ectopic bronchogenic cyst with a low-grade mucinous neoplasm. The patient is currently undergoing outpatient follow-up without recurrence. CONCLUSION An extremely rare case of an abdominal bronchogenic cyst with a low-grade mucinous neoplasm harboring a GNAS mutation was reported.

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