Laparoscopic resection of primary adrenal ganglioneuroma: A case report and review of the literature

Zhou, Yuan; Liang, Qi‐Lian; Ou, Wen‐Ting; Li, Zhouyu; Liu, Qiu-Long

doi:10.3892/ol.2015.3021

Cited by 14 publications

(12 citation statements)

References 23 publications

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“…AGN is the third most common type of GN, accounting for 21%, while 41.5% of GN located in the posterior mediastinum and 37.5% of GN located in retroperitoneum 2 . AGN usually occurs in patients ranging from age 10 to 40, and it most normally affects the right adrenal gland in adults 3 . In present study, AGNs of patient occurs in right adrenal gland as well.…”

Section: Discussionsupporting

confidence: 52%

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A Case Report of Giant Adrenal Ganglioneuroma

Chen

Lin

Jin

et al. 2017

Urology Case Reports

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Adrenal ganglioneuroma (AGN) is an extremely rare and benign entity comprising Schwann cells and ganglion cells. If the lesion approaches to 6 cm, laparoscopic resection is considered as relative contraindication. Now we present a giant adrenal AGN in a 25-year-old male patient. After abdominal computed tomography (CT) scanning, the patient underwent an exploratory laparotomy with right adrenalectomy and histopathological examination further confirmed the lesions as giant AGN, which measured 7 cm × 5 cm × 3.5 cm. Because giant AGN with lesion size greater than 6 cm should be treated by open surgery, it is significant to report the laparoscopic adrenalectomy in patients with large adrenal lesions.

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Section: Discussionsupporting

confidence: 52%

“… 2 AGN usually occurs in patients ranging from age 10 to 40, and it most normally affects the right adrenal gland in adults. 3 In present study, AGNs of patient occurs in right adrenal gland as well.…”

Section: Discussionsupporting

confidence: 51%

A Case Report of Giant Adrenal Ganglioneuroma

Chen

Lin

Jin

et al. 2017

Urology Case Reports

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“…Major vascular resection with prosthetic replacement was also seen for a recurrent retroperitoneal GN (46), but it was recommended to be considered as the last resort and used for recurrent tumors (47). As metastasis and recurrence are rare, previous studies suggest to avoid unnecessary wide excisions and that preservation of surrounding organs and vascular structures should be achieved as far as possible (47,48). Given the fact that recurrence is rarely observed after palliative operation and that combined organ or vascular resection may result in complications, incomplete resection and preservation of neighboring structures should be considered for the stable GNs involving major vessels or organs, unless the tumor is recurrent or potentially invasive.…”

Section: Discussionmentioning

confidence: 99%

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Xiao

Zhao

et al. 2021

Front. Surg.

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Purpose: To investigate the clinical characteristics, diagnosis, differential diagnosis, therapy options, and outcomes of retroperitoneal ganglioneuroma.Methods: In this retrospective study, we collected and analyzed the clinical data of 32 patients diagnosed with retroperitoneal ganglioneuroma and admitted to Peking Union Medical College Hospital from October 2012 to August 2019.Results: Among our 32 cases with retroperitoneal ganglioneuroma, the male-to-female ratio was 1:3 and the mean age was 35. Only 25% of the cases presented with abdominal pain while more than 65% had no specific symptoms. The masses could be found through physical examination in only five patients. Most of the tumors are located near the renal area. They were usually single and displayed an embedded growth pattern with diameters <10 cm, clear borders, and soft texture. For radiological imaging, the majority of tumors demonstrated soft tissue density with mild-to-moderate enhancement on CT imaging and showed hypoecho with moderate blood flow signals in ultrasound. No significantly abnormal laboratory examinations were found in most patients. Of all the 32 patients, 2 chose surveillance after biopsy due to difficulties in operation, while others chose surgical resection. The mean follow-up time was 15.8 months among 26 patients. The tumor remained stable in the surveillance cases. Residual tumors were found in four cases receiving operations with no progress and discomfort. No recurrence was seen in all patients.Conclusions: The retroperitoneal ganglioneuroma is a benign tumor without specific clinical manifestations or significant laboratory findings. Typically, it is shown as low density with a clear border and an embedded growth pattern in radiological imaging. The overall prognosis is good. Surgery is an effective approach with possible severe complications. Incomplete resection or surveillance can be considered for some cases where complete resection is difficult to achieve.

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“…GN are a benign neoplasm in the family of neurogenic tumors that includes neuroblastoma (malignant) and ganglioneuroblastoma (intermediate malignant potential) (1,5,16). GN can arise anywhere along the sympathetic chain and most commonly involve the posterior mediastinum (39-43%) and the retroperitoneum (32-52%) (17). They are less commonly found in the adrenal medulla (21%) (4).…”

Section: Discussionmentioning

confidence: 99%

Dopamine secreting adrenal tumor—ganglioneuroma rather than pheochromocytoma: case report

et al. 2020

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Ganglioneuromas are rare, benign, well-differentiated neural crest tumors arising in the paravertebral sympathetic chain, and are classically non-secretory and clinically asymptomatic. As the diagnosis of ganglioneuroma is based on histopathology, the clinical presentation prior to surgical excision often mirrors that of pheochromocytoma or adrenal cortical adenoma. We describe a case of an incidentally found right sided calcified adrenal mass with evidence of marked dopamine excess, suspicious for pheochromocytoma in a 70-year-old female. The patient endorsed a 6-month history of intermittent right flank pain and a 2-year history of weight loss and fatigue. She reported mild symptoms of hypomania but denied other symptoms of dopamine excess including agitation, anxiety, nausea, and vomiting. Exam revealed isolated mild hypertension. The imaging features of this mass were concerning for malignancy including the presence of macrocalcification and irregular borders. After preoperative alpha blockade, the patient underwent open right adrenalectomy and the final pathology was consistent with ganglioneuroma rather than pheochromocytoma. Following resection, the dopamine level normalized, confirming the resected right adrenal ganglioneuroma as the source of dopamine excess. This case represents a rare presentation of dopamine-secreting adrenal ganglioneuroma. This illustrates that although rare, ganglioneuroma should be included on the differential diagnosis for functional adrenal tumors.

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Laparoscopic resection of primary adrenal ganglioneuroma: A case report and review of the literature

Cited by 14 publications

References 23 publications

A Case Report of Giant Adrenal Ganglioneuroma

A Case Report of Giant Adrenal Ganglioneuroma

Primary Retroperitoneal Ganglioneuroma: A Retrospective Cohort Study of 32 Patients

Dopamine secreting adrenal tumor—ganglioneuroma rather than pheochromocytoma: case report

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