Laparoscopic Sentinel Lymph Node Mapping with Indocyanine Green Using the iSpies Platform: Initial Experience Argentina

Guilmi, Julián Di; Darin, Maria Cecilia; Toscano, Maria Gabriella; Maya, Gustavo

doi:10.1016/j.jmig.2017.09.004

Cited by 5 publications

(8 citation statements)

References 2 publications

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“…21 But the crucial near-infrared (NIR) imaging system may impact the promotion of ICG, especially in countries with limited resources. 8 The overall detection rate of CNPs in our study was of the present related research, and it was found that the bilateral detection rate was 60%. However, the prospective SENTICOL study that used the radiocolloid/blue dye technique reported a bilateral detection rate of 76.5%.…”

Section: Discussionsupporting

confidence: 61%

“…6,7 Although present methods, such as radiocolloid/ blue dye and indocyanine green (ICG), have been widely investigated and accepted, the complicated procedures and high costs of related equipment largely limit its promotion in some cancer centers, highlighting the exploration of an efficient and simple tracer. 8,9 As the only China National Medical Products Administration-approved lymphatic tracer in China, carbon nanoparticles (CNPs) has been widely confirmed with high efficiency in SLN mapping in various solid tumors, such as thyroid carcinoma, colorectal cancer, and breast cancer. [10][11][12] In this study, we share our preliminary experience with the use of CNPs in cervical cancer, aiming to explore its feasibility and effectiveness.…”

Section: Introductionmentioning

confidence: 99%

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Detection of sentinel lymph node in laparoscopic surgery for uterine cervical cancer using carbon nanoparticles

Wang

Zhao

Yuan

et al. 2020

Journal of Surgical Oncology

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Background and Objectives Carbon nanoparticles (CNPs) has been widely confirmed the efficiency in sentinel lymph node (SLN) mapping for various solid tumors. This study aims to explore the feasibility and effectiveness of CNPs during laparoscopic surgery for cervical cancer. Methods We analyzed 45 women with stage IB1‐IIA1 cervical cancer who underwent SLN mapping using CNPs during laparoscopic surgery. The effectiveness of CNPs was evaluated by the detection rate and accuracy parameters. Factors associated with SLN laterality and SLNs localizations were analyzed. Results The overall and bilateral detection rate was 93.3% (42/45) and 60.0% (27/45), respectively. Elevated body mass index was associated with decreased bilateral detection rate (P = .015). A total of 225 SLNs were harvested, with a mean number of 5.0 ± 3.6. A total of 81.3% of SLNs were in expected localizations including external iliac (39.1%), internal iliac (25.8%), and obturator (16.4%) regions, while 18.7% in unusual localizations including common iliac (10.7%), parametrial (7.6%), and presarcal (0.4%) regions. None positive lymph node was found in non‐SLNs with a false‐negative rate of 0%. Conclusion Laparoscopic SLN mapping with CNPs appears to be simple and efficient for patients with early‐stage cervical cancer.

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Section: Discussionsupporting

confidence: 61%

Section: Introductionmentioning

confidence: 99%

Detection of sentinel lymph node in laparoscopic surgery for uterine cervical cancer using carbon nanoparticles

Wang

Zhao

Yuan

et al. 2020

Journal of Surgical Oncology

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“…Previous studies were mainly retrospective, with small sample sizes, and heterogeneity was observed in patient selection and tracer. Moreover, there are some disadvantages to using the most common tracers, such as allergic reactions, radioactive pollution and the cost of and dependence on expensive imaging technology 9‐11 …”

Section: Introductionmentioning

confidence: 99%

Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early‐stage cervical cancer: a prospective study

Qian

Huiqing

et al. 2020

BJOG

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Objective To evaluate the clinical diagnostic validity of carbon nanoparticle suspension (CNS) in sentinel lymph node biopsy (SLNB) for assessing lymphatic spread of early‐stage cervical cancer. Design A prospective study. Setting and population 356 cases. Methods We enrolled 356 stage Ia2‐IIa2 cervical cancer patients to undergo SLNB using CNS, followed by systematic pelvic lymphadenectomy. All lymph node specimens were assessed using conventional histopathologic ± pathologic ultrastaging analyses. Main outcome measures Sentinel lymph node detection rate (DR), clinical diagnostic validity and various related factors were analysed. Results CNS identified 1456 SLNs in 325 patients. The overall SLN DR was 91.29%. A significantly higher DR was found for patients with tumours <20 mm (97.75% versus 71.91%; P < 0.001). Two patients had false‐negative results. SLNB with CNS had sensitivity of 96.65%, false‐negative rate (FNR) of 4.35% and negative predictive value (NPV) of 99.29%. Importantly, sensitivity (100%), NPV (100%) and FNR (0%) were improved when testing the subgroup of patients with tumours <20 mm (267 cases). There were no observed differences in DR based on pathological type or grade, stage, depth of stromal invasion, surgical approach, menopausal status or prior treatment with chemotherapy (P > 0.05). Conclusions Sentinel lymph node biopsy with CNS results in favourable DR, sensitivity and NPV for women with early‐stage cervical cancer with small tumour sizes. SLNB with CNS is safe, feasible and relatively effective for guiding precise surgical treatment of early‐stage cervical cancer. Tweetable abstract Sentinel lymph node biopsy with carbon nanoparticle suspension is safe and feasible for early‐stage cervical cancer.

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“…Eight of 33 patients (24.2%) showed lymph nodes metastasis in final histologic examination with altogether 50 infiltrated lymph nodes (mean 3.1 per pelvic site, range [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19]. In five of these patients, paraaortal lymphonodectomy was carried out with altogether 102 (mean 20.4 per patient) lymph nodes from which 9 lymph nodes in two patients showed metastasis.…”

Section: Resultsmentioning

confidence: 99%

“…Using a foot switch, the surgeon is able to switch between standard white light mode and ICG detection mode in the near infrared band. The system is commonly available and has been used in other large studies .…”

Section: Methodsmentioning

confidence: 99%

Sentinel lymphadenectomy in cervical cancer using near infrared fluorescence from indocyanine green combined with technetium‐99m‐nanocolloid

et al. 2018

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Laparoscopic Sentinel Lymph Node Mapping with Indocyanine Green Using the iSpies Platform: Initial Experience Argentina

Cited by 5 publications

References 2 publications

Detection of sentinel lymph node in laparoscopic surgery for uterine cervical cancer using carbon nanoparticles

Detection of sentinel lymph node in laparoscopic surgery for uterine cervical cancer using carbon nanoparticles

Role of carbon nanoparticle suspension in sentinel lymph node biopsy for early‐stage cervical cancer: a prospective study

Sentinel lymphadenectomy in cervical cancer using near infrared fluorescence from indocyanine green combined with technetium‐99m‐nanocolloid

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