Laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass lead to equal changes in body composition and energy metabolism 17 months postoperatively: a prospective randomized trial

Schneider, Júlia; Peterli, Ralph; Gass, Markus; Slawik, Marc; Peters, Thomas; Wölnerhanssen, Bettina K.

doi:10.1016/j.soard.2015.07.002

Cited by 53 publications

(27 citation statements)

References 35 publications

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“…Our observation revealed that the weight reduction after both procedures is similar (12). In our study percent of EBMIL after LSG, measured 6 months after surgery, was 59.90% (46.75-69.28%) and it was comparable to others authors (13,14). In opposition to LRYGB, mechanisms of diabetes remission after LSG are not well-defined.…”

Section: Discussionsupporting

confidence: 85%

Laparoscopic sleeve gastrectomy for the treatment of diabetes mellitus type 2 patients—single center early experience

et al. 2016

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Background: In recent years, laparoscopic sleeve gastrectomy (LSG) has become one of the most commonly used primary bariatric procedures for morbid obesity. While laparoscopic Roux-en-Y gastric bypass (LRYGB) has well documented positive clinical influence on type 2 diabetes, the role of LSG in diabetes treatment is debatable. The main aim of this study is to present our early experience in LSG as a method of bariatric treatment in patients with type 2 diabetes or abnormalities in glucose homeostasis.Methods: Prospectively collected data of patients operated for morbid obesity at the 2nd Department of Surgery. The study was designed to assess the influence of LSG on type 2 diabetes and glucose homeostasis.The primary endpoint was the diabetes type 2 remission. Secondary endpoint was the change of glucose metabolism parameters after LSG. Patients were assessed preoperatively and allocated to two groups: group 1-with any preoperative abnormalities in glucose homeostasis (prediabetes, diabetes) and group 2-with non-elevated fasting glucose level. During follow-up (6 months after surgery) all glucose homeostasis parameters were analyzed again. One hundred and thirty-six patients after LSG were enrolled in the study (90 females, 46 males; mean age 40.5±9.9 years). Preoperative abnormalities in glucose homeostasis were confirmed in 64 (47%) patients. Twenty (15%) patients in this group had diabetes. Results:We observed significant reduction of body mass index (BMI) after surgery. Mean percent of EBMIL for all groups after 6 months from surgery was 59.90% (46.75-69.28%). There were no full remissions after surgery in patients with preoperative diabetes. We found significant improvement in biochemical markers of glucose homeostasis. We observed significant reduction of HbA1c% after surgery in both groups. The level of postoperative HbA1c% was related to BMI loss after surgery.Conclusions: LSG leads to significant improvement in biochemical glucose homeostasis and can be considered as a method of treatment in morbidly obese patients with glucose metabolism abnormalities. LSG as a method of treatment for patients with clinical type 2 diabetes still needs some further observation.

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Section: Discussionsupporting

confidence: 85%

Laparoscopic sleeve gastrectomy for the treatment of diabetes mellitus type 2 patients—single center early experience

et al. 2016

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“…Bariatric surgery mediates changes to adipose depots, contributing to its effectiveness in treating obesity and its comorbidities [37,38]. Both RYGB and VSG result in comparable, significant loss of fat mass [39][40][41][42][43][44]. One recent study found that both decreases in visceral fat and subcutaneous fat tissue density are sustained one year following RYGB surgery [45].…”

Section: Potential Mechanisms Leading To Weight Loss and Improved Diamentioning

confidence: 99%

Recent advances in the modification of taste and food preferences following bariatric surgery

Primeaux

Silva

Tzeng

et al. 2016

Rev Endocr Metab Disord

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There is a large body of evidence indicating that bariatric surgery provides durable weight loss and health benefits to patients who are obese and have comorbidities such as type 2 diabetes (T2D). However, there are still many questions related to mechanisms of metabolic improvement, predictors of success/failure, and long term consequences, which need to be answered. More recently, there has been a particular interest in the modulation of taste and food preferences that occurs after bariatric surgery and how this affects weight loss in different individuals. Animal models as well as human studies have shed some light on the role of taste in changing food preferences and how these changes may affect weight loss after surgery. The goal of this review is to discuss the physiological and behavioral consequences of bariatric surgery as a treatment for obesity and T2D, with particular emphasis on recent studies describing bariatric surgery-induced modifications in taste perception and food preferences.

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“…Bariatric surgery leads to a marked decrease in fat mass (FM), but fat free mass (FFM) particularly bone mass is also reduced postsurgery, 6 potentially negatively impacting on physical function and strength, and putting patients at increased risk of osteoporotic fracture in the future. 7 8 Moreover, a recent study has revealed a positive association between changes in adiposity with cardiometabolic outcomes postsurgery, indicating the usefulness of incorporating body composition assessment.…”

Section: Introductionmentioning

confidence: 99%

Protocol for a 1-year prospective, longitudinal cohort study of patients undergoing Roux-en-Y gastric bypass and sleeve gastrectomy: the BARI-LIFESTYLE observational study

et al. 2018

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IntroductionRoux-en-Y gastric bypass and sleeve gastrectomy are the two most common bariatric surgery performed in the UK that result in comparable weight loss and remission of obesity-associated comorbidities. However, there is a paucity of studies examining the impact of these procedures on body composition, physical activity levels, sedentary behaviour, physical function and strength, dietary intake, health-related quality of life and costs.Methods and analysisThe BARI-LIFESTYLE observational study is a 1-year prospective, longitudinal cohort study within a real-world routine clinical care setting aiming to recruit 100 patients with severe obesity undergoing either primary Roux-en-Y gastric bypass or sleeve gastrectomy from two bariatric centres in London, UK. Participants will be followed up four times during the study period; presurgery baseline (T0) and at 3 (T1), 6 (T2) and 12 months (T3) postsurgery. In addition to the standard follow-up investigations, assessments including dual-energy X-ray absorptiometry scan, bioelectric impedance analysis, 6 min walk test, sit-to-stand test and handgrip test will be undertaken together with completion of questionnaires. Physical activity levels and sedentary behaviour will be assessed using accelerometer, and dietary intake will be recorded using a 3-day food diary. Outcome measures will include body weight, body fat mass, lean muscle mass, bone mineral density, physical activity levels, sedentary behaviour, physical function and strength, dietary intake, health-related quality of life, remission of comorbidities, healthcare resource utilisation and costs.Ethics and disseminationThis study has been reviewed and given a favourable ethical opinion by London-Dulwich Research Ethics Committee (17/LO/0950). The results will be presented to stakeholder groups locally, nationally and internationally and published in peer-reviewed medical journals. The lay-person summary of the findings will be published on the Centre for Obesity Research, University College London website (http://www.ucl.ac.uk/obesity).

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Laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass lead to equal changes in body composition and energy metabolism 17 months postoperatively: a prospective randomized trial

Cited by 53 publications

References 35 publications

Laparoscopic sleeve gastrectomy for the treatment of diabetes mellitus type 2 patients—single center early experience

Laparoscopic sleeve gastrectomy for the treatment of diabetes mellitus type 2 patients—single center early experience

Recent advances in the modification of taste and food preferences following bariatric surgery

Protocol for a 1-year prospective, longitudinal cohort study of patients undergoing Roux-en-Y gastric bypass and sleeve gastrectomy: the BARI-LIFESTYLE observational study

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