Purpose: Adolescent obesity is striking global health issue in the recent decades. Although non-surgical weight loss strategies have been crucial in obesity management in that age group, they have disappointing results. Consequently, growing interest has emerged on the surface in bariatric surgery for adolescents. Laparoscopic sleeve gastrectomy (LSG) can be an effective treatment option for adolescent obesity and controlling or even eliminating its obesity-related co-morbidities. Methods: Data was collected from the prospectively maintained database between 2014 to 2019 in Gastrointestinal surgical center, Mansoura University. Obese adolescents aged 12-19 years, who underwent LSG with a BMI of more than 40 kg/m2 or a BMI of greater than 35kg/m2 associated with obesity-related comorbidities were included. Results: Forty patients were included in the study: 18 male and 22 female. The median age was 17 years. The mean preoperative body weight and BMI were 147.15 ± 36.31 kg and 52.55 ± 11.61 kg/m2 respectively. Osteoarthritis and depression were the most common comorbidities in the study cohort (14 patients, 35%). After 2 years follow up, the EBWL was 40.84 kg. All patients had achieved %EBWL <50% at 12 months. No nutritional deficiency was encountered in the study period. All obesity related co-morbidities (DM, HTN, OSAS and dyslipidemia) have been resolved. Conclusion: Obese adolescent will grow into obese adult, with increasing burden on health care systems. LSG is feasible, effective, and safe for management of adolescent obesity in the terms of weight loss, resolution of obesity related comorbidities. Long-term follow up is needed in future studies.