Laparoscopic surgery for rectal cancer: preoperative radiochemotherapy versus surgery alone

Abstract

Long-course radiochemotherapy does not have an impact on the feasibility or short-term outcome of laparoscopic conservative rectal excision for rectal cancer.

Anorectal dysfunction after laparoscopic low anterior rectal resection for rectal cancer with and without radiotherapy (manometry study)

“…According to the available data, short‐term outcomes of patients undergoing LAR after neoadjuvant RT are supposed to be less favorable compared to patients without neoadjuvant therapy. In irradiated patients, higher number of peroperative complications (longer operative time, more frequent complications during TME, higher peroperative blood loss) and more frequent postoperative complications have been reported by authors of many available studies …”

“…A higher number of peroperative complications after neoadjuvant RT implicates technically more demanding surgical preparation during LAR. Irradiated pelvis presents significant factor affecting technical difficulty of surgical dissection during total mesorectal excision . A higher postoperative morbidity of patients after neoadjuvant RT is conditioned mainly by compromised ability of irradiated pelvic tissues to heal and thus technically more demanding TME …”

Does neoadjuvant therapy increase the incidence of anastomotic leakage after anterior resection for mid and low rectal cancer? A systematic review and meta‐analysis

“…Twenty‐three studies fulfilled the inclusion criteria and were analysed. A summary of the data and the forest plot used in the estimation of the effect is shown in Fig.…”

“…The effect of the duration of the interval between the end of neoadjuvant therapy and surgery on the postoperative AL rate was evaluated by dividing the studies into two groups, with patients undergoing surgery more or less than 6 weeks after nCRT. Twelve studies were included in this analysis, with seven in the group consisting of patients with an interval of less than 6 weeks and five with an interval of more than 6 weeks. nCRT did not increase the occurrence of AL in either of the groups.…”

“…The primary search identified 2322 abstracts and 23 studies containing 9675 patients who met the inclusion criteria and thus were included in this meta-analysis. Among the included articles, 15 were retrospective cohort studies [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] and eight studies [30][31][32][33][34][35][36][37] were randomized. The screening process is shown in Fig.…”