Laparoscopic treatment of endometriosis and effects on quality of life: A retrospective study using the short form EHP-5 endometriosis specific questionnaire

Abstract

Complete surgical eradication is considered the mainstay of treatment for endometriosis. The aim of the present study was to investigate patients' own assessment of whether their laparoscopic treatment made a difference to their quality of life, as well as to assess local recurrence rates. We performed a retrospective analysis of 49 women who had laparoscopic treatment for endometriosis at our unit between 1 January 2008 and 1 January 2010. Patients were sent the Short Form EHP-5 questionnaire and asked to score their quality of life in relation to endometriosis symptoms, prior to the surgery and up to 48 months afterwards. Subgroup analysis of stage I/II and stage III/IV disease was performed as well as stratification of the period post-operation into 12-24, 25-36 and 37-48 months for follow-up analysis. Overall, the patients reported improvement in quality of life scores with a significant drop in mean scores from 46.9 pre- to 27.5 post-surgery, signifying benefits from the surgical intervention. All subgroups reported improvement in quality of life scores. The overall symptom recurrence rate was 18.3%. We conclude that patients, post-laparoscopic treatment of endometriosis, experience significant improvement in their quality of life, regardless of stage and this can be quantified and qualified.

Development of a French version of the Endometriosis Health Profile 5 (EHP-5): cross-cultural adaptation and psychometric evaluation

“…Indeed, if a treatment results in a difference in QoL, investigators want to be confident that they can detect that difference [18]. The previously discussed study investigated the responsiveness of the English version of the EHP-5 in 40 operated patients [29] and found that mean EHP-5 scores were significantly lower after surgery than before surgery with an important effect size (1.00, from 0.52 to 1.45). It would thus be important to confirm the good responsiveness of the EHP-5 on a broader study with different kind of treatment of endometriosis.…”

“…We have chosen to analyze the dimensional aspect of the 11 items of EHP-5 together and have found excellent internal consistency; we have thus selected to use the sum of the ratings for all of the items to score the EHP-5. A similar method to score was used in a retrospective study using the short form EHP-5 to evaluate the effects on quality of life of the laparoscopic treatment of endometriosis [29]. Furthermore, both studies demonstrate, as our study, the construct validity of their language version of the questionnaire against different characteristics thought to represent the severity of the related symptoms.…”

The short form endometriosis health profile questionnaire (EHP-5): psychometric validity assessment of a Croatian version

“…In opposition to separate dimensional aspect evaluation, French EHP-5 version developers have merged all the ratings from core and modular part of questionnaire [20]. A similar scoring method was applied in retrospective study which have estimated impact of laparoscopic treatment of endometriosis on HRQoL [12]. Regardless of implemented scoring method, all abovementioned studies, including ours, have found adequate internal consistency [11,14,20].…”

“…In order to overcome time impracticality of EHP-30, same group of authors developed Endometriosis Health Pro le-5 (EHP-5) [10]. The EHP-5 questionnaire is proved to be a reliable and valid questionnaire with its special feature in clinical settings where an expeditious endometriosis health status measure is required [10][11][12][13][14].…”

Computational Drug Discovery in Patients with Endometriosis-Induced Infertility via Text Mining and Biomedical Databases

“…De Ziegler et al [27] found that using OC 6-8 weeks before assisted reproduction can also increase the pregnancy rate of assisted reproductive technology. Clinical studies have proved that mifepristone is effective in treating EMT-induced infertility [28].…”