Mirizzi syndrome is an unusual complication of chronic cholelithiasis due to impacted gallstone in the cystic duct or neck of the gallbladder causing Common Bile Duct (CBD) obstruction. Here, we report a case of middle aged female presenting with acute abdominal pain and jaundice. Endoscopic Retrograde Cholangio Pancreatography (ERCP) revealed a large gallstone in the cystic duct compressing the common bile duct suggestive of Mirizzi syndrome which was managed surgically.