Laparoscopy for diagnosing resectability of disease in patients with advanced ovarian cancer

Surgery for Recurrent Epithelial Ovarian Cancer in the Netherlands

“…18 There are still no results of randomized controlled trials providing evidence for the use of diagnostic laparoscopy in predicting outcome in both primary and secondary cytoreductive surgery. 19 In our study, in a small subgroup of patients (n = 38) who had diagnostic surgery to determine resectability before debulking surgery, 92.1% resulted in complete SCS. This suggests that there might be a role for diagnostic laparoscopy combined with clinical factors and imaging to enhance the predictive accuracy for complete secondary cytoreduction.…”

Definition of a dynamic laparoscopic model for the prediction of incomplete cytoreduction in advanced epithelial ovarian cancer: Proof of a concept

“…In all Institutions in which UAS is routinely adopted, and complete PDS is considered the real goal to be pursued, this updated LPS-PI model with a cut-off value of 10 should be applied with better discriminating performances. Further reduction of inappropriate explorations, while maintaining a PPV = 100%, will represent the goal to be pursued for the future development of predictive index models [24]. The proper integration of the LPS-PI with the recently developed molecular [25], and clinico-radiological predictive models [26] including several factors such as age, CT scan findings (thoracic disease, retroperitoneal involvement), CA125 levels and performance status will help to further personalize the decision making process.…”

Does a Standardized Preoperative Algorithm of Clinical Data Improve Outcomes in Patients With Ovarian Cancer? A Quality Improvement Project

“…A recent Cochrane review looked at the literature regarding laparoscopy as a tool to assess tumor resectability. It found that while laparoscopy was useful in many patients, up to 30% of patients had unresectable disease at laparotomy despite a laparoscopy suggesting otherwise 14 . Use of preoperative imaging and CA125 levels has been similarly disappointing 15-18 .…”