“…In accordance with this, CIS of the testis may be detected before puberty in boys with cryptorchidism [19, 22], in males with 45,X/46,XY mosaicism [6, 8], in individuals with androgen insensitivity [23, 24, 25], and in females with 46,XY gonadal dysgenesis [8, 23, 26]. However, testicular biopsy is not a sensitive method for detection of premalignant histological changes before adulthood [27, 28], and the diagnosis may be overlooked. In contrast, a testicular biopsy will detect CIS in almost all cases after puberty [29].…”