Lapatinib and sunitinib on glioma cell migration through implication of growth factor with integrins.

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous population of genetically unstable and highly infiltrative cells that are resistant to chemotherapy. Although substantial efforts have been invested in the field of anti-GBM drug discovery in the past decade, success has primarily been confined to the preclinical level, and clinical studies have often been hampered due to efficacy-, selectivity-, or physicochemical property-related issues. Thus, expansion of the list of molecular targets coupled with a pragmatic design of new small-molecule inhibitors with central nervous system (CNS)-penetrating ability is required to steer the wheels of anti-GBM drug discovery endeavors. This Perspective presents various aspects of drug discovery (challenges in GBM drug discovery and delivery, therapeutic targets, and agents under clinical investigation). The comprehensively covered sections include the recent medicinal chemistry campaigns embarked upon to validate the potential of numerous enzymes/proteins/receptors as therapeutic targets in GBM.

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Glioblastoma: Current Status, Emerging Targets, and Recent Advances

Thakur

Faujdar

Sharma

et al. 2022

J. Med. Chem.

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Lapatinib and sunitinib on glioma cell migration through implication of growth factor with integrins.

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Glioblastoma: Current Status, Emerging Targets, and Recent Advances

Glioblastoma: Current Status, Emerging Targets, and Recent Advances

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