Laponite-based Nanomaterials for Biomedical Applications: A Review

Das, Sabya Sachi; Neelam, .; Hussain, Kashif; Singh, Sima; Hussain, Afzal; Faruk, Abdul; Tebyetekerwa, Mike

doi:10.2174/1381612825666190402165845

Cited by 79 publications

(43 citation statements)

References 129 publications

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“…As shown in Figure 2A, 250-1000 µg/mL of NM increased ALP activity in a dose dependent manner. Similar observations have been reported using osteoblasts grown on laponite nanoparticle gels, akermanite bioceramics, and titania; improvements in bone differentiation markers have also been reported, including accelerated mineralization and increased ALP activity in the bone matrix [49,52,53].…”

Section: Discussionsupporting

confidence: 81%

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Kim

Lee

et al. 2020

Nanomaterials

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Calcium-type montmorillonite, a phyllosilicate mineral, has diverse health benefits when introduced into the gastrointestinal tract or applied to the skin. However, the predominant use of this layered material has thus far been in traditional industries, despite its potential application in the pharmaceutical industry. We investigated the effects and mechanism of nano-montmorillonite (NM) on osteoblast and osteoclast differentiation in vivo and in vitro. We examined the osteogenic effects of NM with high calcium content (3.66 wt%) on alkaline phosphatase (ALP) activity, mineralization, bone microarchitecture, and expression level of osteoblast and osteoclast related genes in Ca-deficient ovariectomized (OVX) rats. Micro-computed tomography of OVX rats revealed that NM attenuated the low-Ca-associated changes in trabecular and cortical bone mineral density. It improved ALP activity and mineralization, as well as the expression of osteoblast and osteoclast differentiation associated genes. NM also activated the expression of runt-related transcription factor 2, osteocalcin, bone morphogenetic protein 2, and type 1 collagen via phosphorylated small mothers against decapentaplegic homolog 1/5/8 signaling. Further, NM repressed the expression of receptor activator for cathepsin K, nuclear factor kappa-B ligand and tartrate-resistant acid phosphatase. Therefore, NM inhibits osteoclastogenesis, stimulates osteoblastogenesis, and alleviates osteoporosis.

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Section: Discussionsupporting

confidence: 81%

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Kim

Lee

et al. 2020

Nanomaterials

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“…12,15 Laponite ® (LP) is a synthetic silicate nanoclay which has already been widely applied in pharmaceutics and cosmetics serving as film-forming agent, emulsifier and gelling agent in surface coatings, cleaners and personal care products. [16][17][18] Nanoclays are 2-dimensional (2D) nanomaterials composed of disk-shaped nanoscale crystals with approximately 25 nm in diameter and 0.92 nm in thickness. 4,7,16,17,19 Within the crystals, layer units composed by two tetrahedral silica sheets sandwich one Mg 2+ -containing octahedral sheet.…”

Section: Introductionmentioning

confidence: 99%

Potential of Laponite® incorporated oxidized alginate–gelatin (ADA‐GEL) composite hydrogels for extrusion‐based 3D printing

2020

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The concept of adding inorganic fillers into hydrogels to form hydrogel nanocomposites often provides advantageous properties which can be exploited for successful 3D biofabrication. In this study, a new composite hydrogel combining oxidized alginate-gelatin (ADA-GEL) hydrogel and Laponite ® nanoclay as inorganic nanofiller was successfully developed and characterized. The results showed that the addition of 0.5% (wt/vol) Laponite ® nanoplatelets improved the printability of ADA-GEL hydrogels enabling the fabrication of detailed structures since a low effect of material spreading and reduced tendency to pore closure appeared. Furthermore, a comparison of different needle types (cylindrical and conical; same inner diameter of 250 μm) in filament fusion test showed that the pattern dispensed by cylindrical tip has enhanced printing accuracy and pattern fidelity when compared with the pattern from conical tip. A glass flip test determined a processing window of 1-2 h after composite ink preparation. Overall, Laponite ® /ADA-GEL hydrogel composites are confirmed as promising inks for 3D bioprinting.

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“…Biopolymers including chitosan, collagen, alginate, and others have been extensively used for the production of stimuli-sensitive scaffolds and associated constructs [ 313 , 314 , 315 , 316 ]. Tissue engineering mediated materials are highly dependent upon cell-associated constructs that provide cellular linkage, progression, propagation, disparity, and relocation [ 317 , 318 ].…”

Section: Applications In Tissue Engineering and Regenerative Medicmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Laponite-based Nanomaterials for Biomedical Applications: A Review

Cited by 79 publications

References 129 publications

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Effect of Nano-Montmorillonite on Osteoblast Differentiation, Mineral Density, and Osteoclast Differentiation in Bone Formation

Potential of Laponite® incorporated oxidized alginate–gelatin (ADA‐GEL) composite hydrogels for extrusion‐based 3D printing

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

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