Laponite for biomedical applications: An ophthalmological perspective

Rodrigo, Maria J.; Cardiel, Maria J.; Fraile, Jose M.; Mayoral, Jose A.; Pablo, Luis E.; Garcia-Martin, Elena

doi:10.1016/j.mtbio.2023.100935

Cited by 4 publications

(1 citation statement)

References 168 publications

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“…Recently, Rodrigo et al [ 114 ] reviewed the latest data regarding the possible use of LAP in the preparation of materials potentially applicable in ophthalmology. Scientific research has shown that LAP can be included in all ocular structures and tissues due to its properties, such as biocompatibility, optical transparency, nanosize, thickness, and thixotropy, which facilitate easy injection and make it a candidate suitable for ophthalmological applications.…”

Section: Laponite ® Applicationsmentioning

confidence: 99%

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Brunchi,

Morariu

2024

Molecules

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Laponite® (LAP) is an intensively studied synthetic clay due to the versatility given by its layered structure, which makes it usable in various applications. This review describes the multifaceted properties and applications of LAP in aqueous dispersions and gel systems. The first sections of the review discuss the LAP structure and the interactions between clay discs in an aqueous medium under different conditions (such as ionic strength, pH, temperature, and the addition of polymers) in order to understand the function of clay in tailoring the properties of the designed material. Additionally, the review explores the aging phenomenon characteristic of LAP aqueous dispersions as well as the development of shake-gels by incorporating LAP. The second part shows the most recent studies on materials containing LAP with possible applicability in the drilling industry, cosmetics or care products industry, and biomedical fields. By elucidating the remarkable versatility and ease of integration of LAP into various matrices, this review underscores its significance as a key ingredient for the creation of next-generation materials with tailored functionalities.

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Section: Laponite ® Applicationsmentioning

confidence: 99%

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Brunchi,

Morariu

2024

Molecules

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Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses

Zheng,

Li,

et al. 2024

Acta Biomaterialia

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Injectable Nanocomposite Hydrogel with Synergistic Biofilm Eradication and Enhanced Re-epithelialization for Accelerated Diabetic Wound Healing

Zhao,

Zhang,

Zhang

et al. 2024

ACS Appl. Mater. Interfaces

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Diabetic wounds remain a critical clinical challenge due to their harsh microenvironment, which impairs cellular function, hinders re-epithelialization and tissue remodeling, and slows healing. Injectable nanocomposite hydrogel dressings offer a promising strategy for diabetic wound repair. In this study, we developed an injectable nanocomposite hydrogel dressing (HDL@ W379) using LAP@W379 nanoparticles and an injectable hyaluronic acid-based hydrogel (HA-ADH-ODEX). This dressing provided a sustained, pH-responsive release of W379 antimicrobial peptides, effectively regulating the wound microenvironment to enhance healing. The HDL@W379 hydrogel featured multifunctional properties, including mechanical stability, injectability, selfhealing, biocompatibility, and tissue adhesion. In vitro, the HDL@W379 hydrogel achieved synergistic biofilm elimination and subsequent activation of basal cell migration and endothelial cell tube formation. Pathway analysis indicated that the HDL@W379 hydrogel enhances basal cell migration through MEK/ERK pathway activation. In methicillin-resistant Staphylococcus aureus (MRSA)-infected diabetic wounds, the HDL@W379 hydrogel accelerated wound healing by inhibiting bacterial proliferation and promoting re-epithelialization, regenerating the granulation tissue, enhancing collagen deposition, and facilitating angiogenesis. Overall, this strategy of biofilm elimination and basal cell activation to continuously regulate the diabetic wound microenvironment offers an innovative approach to treating chronic wounds.

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Laponite for biomedical applications: An ophthalmological perspective

Cited by 4 publications

References 168 publications

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Laponite®—From Dispersion to Gel—Structure, Properties, and Applications

Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses

Injectable Nanocomposite Hydrogel with Synergistic Biofilm Eradication and Enhanced Re-epithelialization for Accelerated Diabetic Wound Healing

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