LAPSER1: a novel candidate tumor suppressor gene from 10q24.3

Cabeza-Arvelaiz, Yofre; Thompson, Timothy C.; Sepulveda, Jorge L.; Chinault, A. Craig

doi:10.1038/sj.onc.1204866

Oncogene

2001

DOI: 10.1038/sj.onc.1204866

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LAPSER1: a novel candidate tumor suppressor gene from 10q24.3

Yofre Cabeza-Arvelaiz

Timothy C. Thompson

Jorge L. Sepulveda

et al.

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Cited by 41 publications

(61 citation statements)

References 36 publications

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“…The leucine zipper putative tumor suppressor (LZTS) gene family encodes a group of closely related proteins involved in transcription modulation and cell cycle control (1). Lzts1/Fez1 is located on chromosomal region 8p22 in humans and ubiquitously expressed in normal tissues (2).…”

mentioning

confidence: 99%

“…Lzts1/Fez1 deficiency was associated with an increased incidence of both spontaneous and carcinogen-induced tumors in mice (3). The Lzts2/ Lapser1 gene was originally identified on the basis of homology with the Lzts1 gene (1). Overall, 38% of the amino acid residues were identical, and 15% were conservative changes between the LZTS1 and LZTS2 proteins.…”

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confidence: 99%

“…The human LZTS2 gene is located on chromosome 10 at 10q24.3, near 10q23.3 where PTEN, a tumor suppressor, was identified (4). LZTS2 is expressed in most normal tissues, with the highest abundance found in testis, prostate, and ovary (1,5). Overexpression of exogenous LZTS2 displayed a repressive effect on cell proliferation in multiple human tumor cell lines (1).…”

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confidence: 99%

“…LZTS2 is expressed in most normal tissues, with the highest abundance found in testis, prostate, and ovary (1,5). Overexpression of exogenous LZTS2 displayed a repressive effect on cell proliferation in multiple human tumor cell lines (1). The third member of the LZTS family, LZTS3, was identified on human chromosome 20p13 and is mainly expressed in brain and kidney tissues (6).…”

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confidence: 99%

“…S1. 1 To whom correspondence should be addressed: Depts. of Urology and Genetics, S287, Grant Bldg., Stanford University School of Medicine, Stanford, CA 94305-5328.…”

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confidence: 99%

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The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development

Peng

Clark

Luong

et al. 2011

Journal of Biological Chemistry

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Background:The LZTS2 is a novel ␤-catenin-interacting protein, and its role in development and tumorigenesis is unknown. Results: Lzts2 KO mice show severe kidney and urinary tract developmental defects, including renal/ureteral duplication, hydroureter, and hydronephrosis. Conclusion: LZTS2 plays a critical role in kidney and urinary tract development. Significance: A novel mechanism by which LZTS2 regulates ␤-catenin mediated nephrogenesis is implicated.

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confidence: 99%

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confidence: 99%

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confidence: 99%

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confidence: 99%

“…S1. 1 To whom correspondence should be addressed: Depts. of Urology and Genetics, S287, Grant Bldg., Stanford University School of Medicine, Stanford, CA 94305-5328.…”

mentioning

confidence: 99%

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The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development

Peng

Clark

Luong

et al. 2011

Journal of Biological Chemistry

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Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials

Othus

Davison

et al. 2017

Cancer

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Background Aberrant DNA methylation is known to occur in acute myeloid leukemia (AML), while methylation signatures and prognostic markers have been proposed. This study aimed to evaluate all CpG sites of the genome and identify prognostic methylation markers for overall survival in AML patients with normal cytogenetics (AML-NK). Methods AML-NK samples from seven SWOG trials were analyzed using a novel genome-wide approach “CHARMcox”: the comprehensive high-throughput array-based relative methylation analysis combined with the Cox proportional hazard model controlling for known clinical covariates. CHARMcox was applied to a phase I discovery cohort (n=72) to identify survival associated methylation regions (SAMRs). Subsequently, using bisulfite pyrosequencing, SAMRs were studied in phase II model building (n=65) and phase III validation (n=65) cohorts. An independent external cohort from the TCGA AML study (LAML) was used for further validation (n=93). Results Two SAMRs, located at the CpG island shores of LZTS2 and NR6A1, respectively, were identified. Multivariable analyses demonstrated that hypomethylation of either LZTS2 or NR6A1 was associated with worse overall survival in the SWOG cohort (P < 0.001). The prognosis was validated in AML-NK patients from the TCGA-LAML cohort. Methylation values below median at both markers predicted worse overall survival (SWOG, HR 1.89, P <0.001; TCGA-LAML, HR 2.08, P=0.006). The C-statistics was 0.71 for both cohorts, and the impact was independent of the FLT3-ITD status. Conclusions The two methylation markers, measurable by clinically applicable assays such as bisulfite pyrosequencing, are promising for risk stratification among AML patients with normal karyotype.

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The spatio‐temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development

Gessert¹,

Schmeißer²,

Si³

et al. 2011

Developmental Dynamics

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Members of the ProSAP/Shank family are important scaffolding proteins of the postsynaptic density (PSD). We investigated for the first time the expression of the three family members named Shank1, ProSAP1/Shank2, and ProSAP2/Shank3 during Xenopus laevis development. Shank1 is expressed in the neural tube, the retina, and the cranial ganglions. In contrast, ProSAP1/Shank2 transcripts could be visualized in the otic vesicle, the pronephros, the liver, the neural tube, and the retina. ProSAP2/Shank3 could be detected in the cardiovascular network, the neural tube, the pronephros, and the retina. Furthermore, we showed that LAPSER1 interacts with all three ProSAP/Shank family members in Xenopus embryos and co‐localizes with ProSAP/Shank in a cell‐based assay. In Xenopus, LAPSER1 is expressed in somites, brain, proctodeum, pronephros, and in some cranial ganglions. Thus, we suggest that members of the ProSAP/Shank family and LAPSER1 not only play a role in PSD formation and plasticity, but also during embryonic development. Developmental Dynamics 240:1528–1536, 2011. © 2011 Wiley‐Liss, Inc.

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LAPSER1: a novel candidate tumor suppressor gene from 10q24.3

Cited by 41 publications

References 36 publications

The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development

The Leucine Zipper Putative Tumor Suppressor 2 Protein LZTS2 Regulates Kidney Development

Prognostic methylation markers for overall survival in cytogenetically normal patients with acute myeloid leukemia treated on SWOG trials

The spatio‐temporal expression of ProSAP/shank family members and their interaction partner LAPSER1 during Xenopus laevis development

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