Larch Arabinogalactan

Adams, Mark F.; Ettling, Bruce V.

doi:10.1016/b978-0-12-746252-3.50023-x

Cited by 6 publications

(6 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Type II AGs contain frameworks of 3-, 6-, and 3,6-linked b-D D-Galp residues that are substituted with a-L L-Araf and other sugars to varying extents, including uronic acids and other neutral monosaccharides. 38,40,41,46 Type II AGs attached to protein (AGPs) have attracted considerable attention and are thought to participate in several aspects of the life cycle of plants such as vegetative, reproductive and cell growth and development, molecular interactions and signalling, among others. 40,47 A third type contains arabinogalactan side chains attached to other polysaccharides.…”

Section: Discussionmentioning

confidence: 99%

Isolation, characterization and structural determination of a unique type of arabinogalactan from an immunostimulatory extract of Chlorella pyrenoidosa

Suárez

Kralovec²,

Noseda

et al. 2005

Carbohydrate Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Isolation, characterization and structural determination of a unique type of arabinogalactan from an immunostimulatory extract of Chlorella pyrenoidosa

Suárez

Kralovec²,

Noseda

et al. 2005

Carbohydrate Research

View full text Add to dashboard Cite

“…It has been an exceptional business case that hemicelluloses (arabinogalactans) from larch wood could be extracted with warm water at a high yield (30% of wood biomass), which allowed cost-competitive commercial production during the era of rapid growth of the fossil-based polymer industry. 13 Most raw materials are more recalcitrant regarding hemicellulose extraction. When water is heated to above 100 °C in a closed vessel, the pressure increases, the physicochemical water properties change (increase of the ionization constant, decrease of surface tension, dielectric constant, viscosity), and water becomes a good solvent for hemicelluloses.…”

Section: Introductionmentioning

confidence: 99%

Hot-Water Hemicellulose Extraction from Fruit Processing Residues

et al. 2022

View full text Add to dashboard Cite

Hemicelluloses are an abundant biopolymer resource with interesting properties for applications in coatings and composite materials. The objective of this investigation was to identify variables of industrially relevant extraction processes that increase the purity of hemicelluloses extracted from fruit residues. Our main finding is that extraction with subcritical water, followed by precipitation with alcohol, can be adjusted to yield products with a purity of at least 90%. Purity was determined based on the total concentration of glucose, galactose, xylose, arabinose, and mannose after hydrolysis with sulfuric acid. In the first experimental design (DoE methodology), the effects of extraction temperature (95–155 °C) and time (20–100 min) on yield and purity were studied. A clear trade-off between yield and purity was observed at high temperatures, indicating the selective removal of impurities. In the second experimental design, the influence of extract pH and alcohol concentration on yield and purity was investigated for the raw extract and a concentrate of this extract with 1/6 of the original volume. The concentrate was obtained by ultrafiltration through ceramic hollow-fiber membranes. The highest purity of 96% was achieved with the concentrate after precipitating with 70% alcohol. Key factors for the resource efficiency of the overall process are addressed. It is concluded that extraction with subcritical water and ultrafiltration are promising technologies for producing hemicelluloses from fruit residues for material applications.

show abstract

“…Acute toxicity studies in rat or mice showed that even 5000 mg/kg body weight led to no symptoms of toxicity. In long term studies 500 mg/kg body weight over 90 days showed no toxic effects (for review see [2,3]).…”

Section: Discussionmentioning

confidence: 99%

“…In nature, arabinogalactans are found in microbial systems and plants. As part of the cell walls they can be found in several plants with immune-enhancing properties like Echinacea purpurea or Curucuma long but also many other plants such as carrots, radish, pears, or maize [1][2][3][4]. They are a very heterogeneous class of molecules, depending on the herbal source.…”

Section: Introductionmentioning

confidence: 99%

“…are water soluble, nitrogen-free highly branched molecules composed of galactose and arabinose units in a 6:1 ratio, with trace amounts of glucuronic acid. Larch arabinogalactan has a galactan backbone that features β (1,3) linkages and galactose β (1,6) and arabinose β(1, 6 and 1, 3) sugar side chains [2]. In contrast to larch typically the concentrations of arabinogalactan in non-larch arabinogalactan other sources is low (0.5% -2%) whereas in larch arabinogalactan used for ResistAid™ the proportion is approximately 85%.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tolerability of a Proprietary Larch Arabinogalactan Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial in Healthy Subjects

Grube¹,

Stier²,

Riede³

et al. 2012

FNS

View full text Add to dashboard Cite

In a placebo-controlled, double-blind, randomized clinical trial, the tolerability of a proprietary larch arabinogalactan preparation (ResistAid?) was investigated. METHODS: 199 healthy participants were randomly assigned to receive either placebo (n = 98) or an arabinogalactan preparation (n = 101) over a period of 12 weeks. As safety parameters the total number of adverse events, changes in various biochemical and laboratory parameters as well as the global evaluation of tolerability by investigator and subjects compared to placebo were evaluated. RESULTS: In total 16 adverse events were observed in 16 subjects, with no difference between the arabinogalactan and the placebo group (p = 0.935). There were no differences in the mean changes of the measured biochemical and laboratory parameters. The tolerability of the arabinogalactan extract was rated as “very good” or “good” by the investigators for 99% of the subjects and by 98% subjects in self-assessment with no statistical differences to placebo. CONCLUSION: The measured parameters as well as the evaluation of the tolerability by the investigators and the subjects demonstrate a very good tolerance profile of the proprietary arabinogalactan extract with no differences to placebo when taken for 12 weeks

show abstract

Larch Arabinogalactan

Cited by 6 publications

References 41 publications

Isolation, characterization and structural determination of a unique type of arabinogalactan from an immunostimulatory extract of Chlorella pyrenoidosa

Isolation, characterization and structural determination of a unique type of arabinogalactan from an immunostimulatory extract of Chlorella pyrenoidosa

Hot-Water Hemicellulose Extraction from Fruit Processing Residues

Tolerability of a Proprietary Larch Arabinogalactan Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial in Healthy Subjects

Contact Info

Product

Resources

About