Large and small platelets—(When) do they differ?

Handtke, Stefan; Thiele, Thomas

doi:10.1111/jth.14788

Cited by 90 publications

(85 citation statements)

References 139 publications

(209 reference statements)

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“…Platelet size positively correlates with surface receptor number and platelet ATP content. The number of ribosomes is higher in large platelets and they incorporate more amino acids, suggesting a higher potential for protein synthesis [ 57 ]. Larger platelets have increased hemostatic potential, bind more fibrinogen, and have greater levels of phosphorylation after thrombin stimulation than smaller platelets [ 57 ].…”

Section: Plateletsmentioning

confidence: 99%

The Impact of COVID-19 Disease on Platelets and Coagulation

2020

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Coronavirus disease 2019 (COVID-19) causes a spectrum of disease; some patients develop a severe proinflammatory state which can be associated with a unique coagulopathy and procoagulant endothelial phenotype. Initially, COVID-19 infection produces a prominent elevation of fibrinogen and D-dimer/fibrin(ogen) degradation products. This is associated with systemic hypercoagulability and frequent venous thromboembolic events. The degree of D-dimer elevation positively correlates with mortality in COVID-19 patients. COVID-19 also leads to arterial thrombotic events (including strokes and ischemic limbs) as well as microvascular thrombotic disorders (as frequently documented at autopsy in the pulmonary vascular beds). COVID-19 patients often have mild thrombocytopenia and appear to have increased platelet consumption, together with a corresponding increase in platelet production. Disseminated intravascular coagulopathy (DIC) and severe bleeding events are uncommon in COVID-19 patients. Here, we review the current state of knowledge of COVID-19 and hemostasis.

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Section: Plateletsmentioning

confidence: 99%

The Impact of COVID-19 Disease on Platelets and Coagulation

2020

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“…Platelets are an important element of hemostasis and are involved in many physiological and pathological processes, including an important modulation of inflammatory responses [ 72 ]. Most of the papers reviewed here did not indicate the presence of thrombocytopenia or platelet differences between patients with severe disease and those exhibiting mild disease [ 32 , 33 , 44 , 45 , 46 , 47 ].…”

Section: Hematologic Symptoms Of Severe Acute Respiratory Syndromementioning

confidence: 99%

Coronavirus Disease 2019 (COVID–19): A Short Review on Hematological Manifestations

2020

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Infection with severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) is a rapidly spreading and devastating global pandemic. Many researchers are attempting to clarify the mechanisms of infection and to develop a drug or vaccine against the virus, but there are still no proven effective treatments. The present article reviews the common presenting hematological manifestations of coronavirus disease 2019 (COVID–19). Elucidating the changes in hematological parameters in SARS–CoV–2 infected patients could help to understand the pathophysiology of the disease and may provide early clues to diagnosis. Several studies have shown that hematological parameters are markers of disease severity and suggest that they mediate disease progression.

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“…An emerging notion is that the interplay between PDW and MPV should be considered when evaluating their [21]. The ploidy of megakaryocytes has been observed to correlate with the MPV [22]. Moreover, platelets with a high MPV have been confirmed to be a potential indicator of platelet activation [23].…”

Section: Development and Validation Of A Novel Staging Systemmentioning

confidence: 99%

“…Moreover, platelets with a high MPV have been confirmed to be a potential indicator of platelet activation [23]. Larger platelets contain higher absolute amounts of proteins and more receptors on the surface, which enables them to interact with tumor cells [22]. For example, during the process of platelet activation, granules containing ADP released by platelets [20] interact with P2Y12 receptors on platelets, triggering epithelial-mesenchymal transition, followed by invasion and metastasis [24].…”

Section: Development and Validation Of A Novel Staging Systemmentioning

confidence: 99%

“…In addition, increased platelet turnover is often observed in cancer patients, possibly arising from increased platelet consumption or sequestration. When platelet turnover increases, new platelets are produced with a larger size[22].Whether larger platelets are more prothrombotic remains unclear. Evidence clarifying the role of small platelets in cancerassociated thrombosis is limited.…”

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confidence: 99%

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Comparison of the Prognostic Value of Platelet-Related Indices in Biliary Tract Cancer Undergoing Surgical Resection

et al. 2021

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Platelet-related indices, including mean platelet volume (MPV) and plateletocrit (PCT), have been reported as new prognostic factors of overall survival (OS) in many cancers, but not yet in biliary tract cancer (BTC). We intended to assess these indices in predicting OS in BTC patients with the aim to build a new prognostic model for patients with BTC after surgical resection. Materials and methods Survival analysis and time receiver operating characteristic (time-ROC) analysis were applied to screen the platelet indices. Univariate and multivariate Cox analyses were used to identify independent prognostic factors and develop a new prognostic model. Harrell's C-statistics, calibration curves, and decisive curve analysis (DCA) were used to assess the model. Results MPV and platelet distribution width (PDW)/PCT showed the best prognostic accuracy among the platelet indices. In multivariable analysis, factors predictive of poor OS were presence of nodal involvement, Non-radical surgery, poor tumor differentiation, carbohydrate antigen 19-9 > 100 U/mL, MPV > 8.1 fl, and PDW/PCT > 190. The new model was found to be superior to the TNM staging system and our new staging system showed higher discriminative power. Conclusion MPV and PDW/PCT have high prognostic value in BTC patients, and the novel staging system based on these two indices showed good discrimination and accuracy compared with the American Joint Committee on Cancer 7th TNM staging system.

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Large and small platelets—(When) do they differ?

Cited by 90 publications

References 139 publications

The Impact of COVID-19 Disease on Platelets and Coagulation

The Impact of COVID-19 Disease on Platelets and Coagulation

Coronavirus Disease 2019 (COVID–19): A Short Review on Hematological Manifestations

Comparison of the Prognostic Value of Platelet-Related Indices in Biliary Tract Cancer Undergoing Surgical Resection

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