Large Animal Models of Glioma: Current Status and Future Prospects

Hicks, William H; Bird, Cylaina E; Pernik, Mark N.; Haider, Ali S; Dobariya, Aksharkumar; Abdullah, Kalil G.; Aoun, Salah G.; Bentley, R. Timothy; Cohen-Gadol, Aaron; Bachoo, Robert; Mickey, Bruce; Pascual, Juan M.; Ahmadieh, Tarek Y. El

doi:10.21873/anticanres.15347

Cited by 24 publications

(14 citation statements)

References 85 publications

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“…Several reproducible glioma models in pigs are evolving as preclinical large-animal models (326)(327)(328)(329). Therefore, xenograft and genetically engineered porcine models are suggested as reliable prospective models to allow for a transitional step between murine models and human clinical trials (330).…”

Section: Discussionmentioning

confidence: 99%

Molecular targeted therapy: A new avenue in glioblastoma treatment (Review)

et al. 2022

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Glioblastoma, also referred to as glioblastoma multiforme (GBM), is grade IV astrocytoma characterized by being fast-growing and the most aggressive brain tumor. In adults, it is the most prevalent type of malignant brain tumor. Despite the advancements in both diagnosis tools and therapeutic treatments, GBM is still associated with poor survival rate without any statistically significant improvement in the past three decades. Patient's genome signature is one of the key factors causing the development of this tumor, in addition to previous radiation exposure and other environmental factors. Researchers have identified genomic and subsequent molecular alterations affecting core pathways that trigger the malignant phenotype of this tumor. Targeting intrinsically altered molecules and pathways is seen as a novel avenue in GBM treatment. The present review shed light on signaling pathways and intrinsically altered molecules implicated in GBM development. It discussed the main challenges impeding successful GBM treatment, such as the blood brain barrier and tumor microenvironment (TME), the plasticity and heterogeneity of both GBM and TME and the glioblastoma stem cells. The present review also presented current advancements in GBM molecular targeted therapy in clinical trials. Profound and comprehensive understanding of molecular participants opens doors for innovative, more targeted and personalized GBM therapeutic modalities.

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Section: Discussionmentioning

confidence: 99%

Molecular targeted therapy: A new avenue in glioblastoma treatment (Review)

et al. 2022

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“…Canine, porcine and non-human primate models have shown promise in GBM, and will be particularly useful transitional models to bridge the translational gap from mice to humans (Hicks et al 2021).…”

Section: Discussionmentioning

confidence: 99%

Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors

Talele

Zhang

Chen

et al. 2022

J Pharmacol Exp Ther

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2. Introduction -673 3. Discussion -1603 (after incorporating reviewers' comments) Non-standard abbreviations -ABC -Adenosine tri-phosphate binding cassette, ATM -ataxia telangiectasia mutated kinase, AUC -area under the curve, Bcrp -breast cancer resistance protein, CL -clearance, CNS -This article has not been copyedited and formatted. The final version may differ from this version.JPET Fast Forward.

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“…In addition, EGCG could prevent the alveolar bone resorption that occurs in periodontal diseases, by inhibiting the expression of MMP-9 in osteoblasts and the formation of osteoclasts [28]. Other studies also show the immunostaining of MMP-2 and MMP-9 in osteoblasts, however, in the respective studies, rats and mice were used as an experimental animal model [29]. In the present study we use beagle dogs as model for histopathological study of apical periodontitis due its anatomical and physiopathological similarities with humans.…”

Section: Discussionmentioning

confidence: 99%

Effect of epigallocatechin-3-gallate (EGCG) - based paste as intracanal dressing, in matrix metalloproteinases 2 and 9 in dog’s periapical lesions

Rossi

Pradela

Liévana

et al. 2022

Preprint

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Objectives: High expression of MMP-2 and MMP-9 in periapical lesions plays an important role in the degradation of the extracellular matrix. This study aimed to investigate the effect of epigallocatechin-3-gallate (EGCG)-based endodontic paste as an intracanal dressing on the expression of MMP-2 and MMP-9 in periapical lesions. Materials and Methodss: Periapical lesions were experimentally induced in 35 mature beagle dog premolars randomly divided into healthy teeth, untreated periapical lesions, periapical lesionstreated in a single session, and periapical lesions treated in two sessions with EGCG or calcium hydroxide-based pastes. The operator monitored the animals and performed euthanasia after 120 days for histopathologic and immunofluorescence analyses to assess the expression of MMP-2 and MMP-9. Then we perform the statistical analysis. Results: Endodontic treatment in two sessions using EGCG and calcium hydroxide-based pastes provided similar levels of repair of the apical and periapical tissues and neoformation of periodontal ligament fibers, cementum and alveolar bone. In both groups, the expression of MMP-2 and MMP-9 was minimal,and it was observed in the cytoplasm of fibroblasts, osteoblasts, cementoblasts, cementocytes and vascular endothelium. In healthy teeth, the expression of MMPs was minimal and was found in odontoblasts. Endodontic treatment in a single session did not result in full repair of periapical lesions, and they presented intense expression of MMP-2 and MMP-9, including in the cytoplasm of persistent inflammatory cells, similar to untreated lesions. In both groups treated in two sessions, the expression of MMP-2 and MMP-9 was similar to that in healthy teeth, and it was significantly lower than that in periapical lesions treated in a single session or untreated (p <0.001). Conclusions: The use of EGCG-based endodontic paste reduced the expression of MMP-2 and MMP-9 and allowed for the repair of periapical lesions, similar to calcium hydroxide-based paste, and it was superior to treatment performed in a single session. Clinical Relevance: This study was the first one that evaluated the use of EGCG- based paste as intracanal treatment resulted in a reduction of the expression of MMPs 2 and 9 and repair of periapical lesions, similarly to calcium hydroxide-based paste.

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Large Animal Models of Glioma: Current Status and Future Prospects

Cited by 24 publications

References 85 publications

Molecular targeted therapy: A new avenue in glioblastoma treatment (Review)

Molecular targeted therapy: A new avenue in glioblastoma treatment (Review)

Central Nervous System Distribution of the Ataxia-Telangiectasia Mutated Kinase Inhibitor AZD1390: Implications for the Treatment of Brain Tumors

Effect of epigallocatechin-3-gallate (EGCG) - based paste as intracanal dressing, in matrix metalloproteinases 2 and 9 in dog’s periapical lesions

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