SA mechanoreceptors (e.g., Merkel disk and Ruffini cylinder) are distributed near the skin surface and can produce sustained signals in response to static touch or pressure (Figure 1a). FA mechanoreceptors (e.g., Meissner corpuscle and Pacinian corpuscle) respond only at the beginning and/or ending moments of stimulation and can detect dynamic vibration or sliding (Figure 1a). To mimic these functions of human skin, artificial sensors have been developed utilizing different sensing mechanisms. Particularly, resistive, capacitive, and transistor-based sensors are suitable to mimic SA mechanoreceptors as they can maintain the signal produced by a static stimulus, [4-6] whereas triboelectric and piezoelectric sensors can generate instantaneous signal output and are capable of mimicking FA mechanoreceptors. [1,7] Nevertheless, sensors based on a single sensing mechanism have only one type of signal output with limited information interpreted, restricting the scenarios of their practical applications. To meet the requirement for resolving complex stimuli in the emerging fields of artificial prosthetics, humanoid robotics, and wearable healthcare devices, sensing devices that can imitate both SA and FA functions are in high demand. Numerous efforts have been made to approach this goal in recent years and two major strategies have been developed. One strategy is spatial integration of different sensing elements into one platform. [8-12] For example, a fingertip-like sensor that can discriminate lateral sliding and vertical pressure is developed by spatially combining triboelectric and piezoresistive sensing elements. [8] Besides, a self-powered sensor for mimicking SA and FA has been developed based on spatial integration of an ion-channel system and a piezoelectric film. [10] This spatial integration strategy is straightforward and the individual sensing elements can work independently. Nevertheless, the fabrication processes are complicated and the devices are bulky. Another strategy is the merging of different sensing principles to fabricate multimode sensing devices. [13-18] For instance, flexible sensors that can detect different mechanical stimuli (e.g., pressure, strain, flexion, etc.) have been developed. [13,14] In Human skin is equipped with slow adapting (SA) and fast adapting (FA) capabilities simultaneously. To mimic such functionalities, elaborately designed devices have been explored by integrating multiple sensing elements or adopting multimode sensing principles. However, the complicated fabrication, signal mismatch of different modules, complex operation, and high power-consumption hinder their widespread applications. Here, a new type of single-mode and self-powered mechanoreceptor that can mimic both SA and FA via seamless fusion of complementary while compatible potentiometric and triboelectric sensing principles is reported. The resultant potentiometric-triboelectric hybridized mechanoreceptor exhibits distinctive features that are hard to achieve via currently existing methods, including single-mo...