Large artery biomechanics and diastolic dysfunctionin patients with Type 2 diabetes

Soldatos, Georgia; Jandeleit-Dahm, K.; Thomson, Helen L.; Formosa, Melissa F.; D’Orsa, K.; Calkin, Anna C.; Cooper, MB; Ahimastos, Anna A.; Kingwell, Bronwyn A.

doi:10.1111/j.1464-5491.2010.03146.x

Cited by 26 publications

(19 citation statements)

References 32 publications

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“…Also when assessed for co-relation between glycaemic control and diastolic dysfunction, the obtained value in the present study is 'P' < 0.002. This result is in concordance with study results of Soldatos et al, [3] who in their case control study of 55 individuals with type-2 DM concluded that diastolic dysfunction, present in a significant proportion of diabetic persons.…”

Section: Resultssupporting

confidence: 83%

A Study of Diastolic Dysfunction and Factors Influencing Diastolic Function in Diabetes Mellitus Patients in Chengalpattu Medical College and Hospital

Rao¹,

Kumaran²,

Venkateswari³

2016

jemds

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A cross-sectional study on diastolic function and factors influencing diastolic function in diabetes mellitus patients with normal systolic function was done in Chengalpattu Medical College during the period of 2015-2016. All patients with type 2 DM of age 40-80 years, duration of type 2 DM more than 5 years and with normal left ventricular systolic function was included in the study. Subjects with h/o angina, chest pain, ECG changes, abnormal treadmill test, evidence of valvular disease, hypertension and subjects with poor transthoracic ECHO window were excluded from study. The prevalence of diastolic dysfunction in asymptomatic type 2 DM patients is high and found to be 72% in the present study. The occurrence of diastolic dysfunction seems to precede the occurrence of systolic dysfunction in diabetes patients. There is a significant correlation between duration of diabetes, glycaemic control, age, obesity, dyslipidaemia and diastolic dysfunction among the seven parameters considered in the present study. Early diagnosis and initiation of appropriate treatment for diastolic dysfunction would slow down the progression to diastolic heart failure and cause significant reduction in the mortality and morbidity in patients with diabetes.

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Section: Resultssupporting

confidence: 83%

A Study of Diastolic Dysfunction and Factors Influencing Diastolic Function in Diabetes Mellitus Patients in Chengalpattu Medical College and Hospital

Rao¹,

Kumaran²,

Venkateswari³

2016

jemds

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show abstract

“…The classic echocardiographic and Doppler parameters have some limitations for the diagnosis of diastolic dysfunction because there is no clear and definitive diagnostic criterion [6][7][8][9][10][11][12][13][14][15][16][17]. Tissue Doppler imaging (TDI) is relatively a new technique and sensitive method that measures the velocity of the longitudinal motion (shortening and lengthening) of the mitral annulus and has an important role for early diagnosis of diastolic impairment in diabetic patients who may benefit from earlier treatment in order to prevent the progression to clinically overt heart failure [18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Early Detection of Diastolic Dysfunction in Diabetic Patients (Single Center Cross Sectional Study)

Ashour¹

2018

J Heart Cardiovasc Res

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“…Several trials have investigated treatment of hypertension as a way of reducing risk of ASCVD events (3,52,(54)(55)(56). The observed benefits of BP-lowering therapies have been inferred primarily from larger trials that included only subsets of older subjects with diabetes (12).…”

Section: Bpmentioning

confidence: 99%

Management of Atherosclerotic Cardiovascular Disease Risk Factors in the Older Adult Patient With Diabetes

Korytkowski

Forman

2017

Diabetes Care

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Older adults with diabetes are at higher risk for atherosclerotic cardiovascular disease (ASCVD) than younger adults with diabetes and older adults without diabetes. The rationale to implement ASCVD risk-lowering therapies in older adults with diabetes is compelling. Recommendations for lifestyle modification, lipidlowering therapy, blood pressure management, blood glucose control, and aspirin therapy are often based on studies that show their efficacy in younger populations. However, the risks associated with each of these interventions increase with age, and favorable risk-to-benefit ratios demonstrated in younger adults with diabetes are less certain in older populations. The variability in health status among older adults is pertinent. Those with robust health are more likely to tolerate and derive benefit from many therapies when compared with those who have more complex health including frailty. Age-and/or frailty-stratified data to help clarify these relationships are sparse. In this Perspective, current recommendations for modifying ASCVD risk are described with a review of the pertinent literature that guides their application in older adults. A pragmatic approach to the treatment of ASCVD risk factors in older adults with diabetes is presented.Diabetes is highly prevalent in the aging population, affecting .25% of individuals aged .65 years and 19% of those aged .75 years (1,2). Physiological changes associated with aging increase susceptibility to coronary heart disease and other atherosclerotic cardiovascular disease (ASCVD) processes (3). The incidence and prevalence of ASCVD-related macrovascular events essentially doubles in older adults with diabetes (4-6). The overlap of older age, diabetes, and other ASCVD risk factors enhances risk for microvascular and macrovascular complications, functional disability, and geriatric syndromes (including frailty, multimorbidity, polypharmacy, cognitive impairment, depression, urinary incontinence, and falls) (1,7-10). As the population of older adults grows, the implications of diabetes on ASCVD risk escalate, and insights regarding optimal care become increasingly important (2).Therapies directed at ASCVD risk factor reduction are important therapeutic priorities for older adults with diabetes as a way of modifying risk for vascular events and improving health-related quality of life (HRQL) (11,12). Therapeutic targets include control of lipids, blood pressure (BP), and blood glucose in combination with antiplatelet agents. The expectation is that these therapies will increase longevity, reduce ASCVD events and need for hospitalizations, and improve HRQL. However, iatrogenic risks and limited life expectancy confound these objectives

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Large artery biomechanics and diastolic dysfunctionin patients with Type 2 diabetes

Cited by 26 publications

References 32 publications

A Study of Diastolic Dysfunction and Factors Influencing Diastolic Function in Diabetes Mellitus Patients in Chengalpattu Medical College and Hospital

A Study of Diastolic Dysfunction and Factors Influencing Diastolic Function in Diabetes Mellitus Patients in Chengalpattu Medical College and Hospital

Early Detection of Diastolic Dysfunction in Diabetic Patients (Single Center Cross Sectional Study)

Management of Atherosclerotic Cardiovascular Disease Risk Factors in the Older Adult Patient With Diabetes

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