1984
DOI: 10.1016/s0167-8140(84)80065-1
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Large bowel stenosis in rats after fractionated local irradiation

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Cited by 43 publications
(9 citation statements)
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“…These findings have demonstrated that the suitable day to evaluate irradiation-induced rectal damage is the 10th day after irradiation. The pathologic findings were consistent with those from previous reports (15)(16)(17)(18)(19)(20)(21)(22)(23) and were also consistent with the pathologic findings of radiation proctitis in the human rectum (29).…”
Section: Discussionsupporting
confidence: 91%
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“…These findings have demonstrated that the suitable day to evaluate irradiation-induced rectal damage is the 10th day after irradiation. The pathologic findings were consistent with those from previous reports (15)(16)(17)(18)(19)(20)(21)(22)(23) and were also consistent with the pathologic findings of radiation proctitis in the human rectum (29).…”
Section: Discussionsupporting
confidence: 91%
“…Experimental animal models of radiation-induced gastrointestinal toxicities have been described in previous studies (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28). However, irradiation plus differing surgical techniques could have produced different results.…”
Section: Discussionmentioning
confidence: 99%
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“…In the intestine, the multitude of cell types as well as the possible relationship between early and late changes compiicate such analyses. In a study with fractionated irradiation of rat sigmoid colon using intestinal obstruction as an endpoint, none of the currently used models adequately predicted late changes (169). On the other hand, a / p ratios calculated from various endpoints following fractionated irradiation of rectum in mice were consistent with the linear-quadratic theory, i.e.…”
Section: Effects Of Dose Fractionationmentioning
confidence: 85%