Large Cell Neuroendocrine Carcinoma of the Cervix Associated with Adenocarcinoma In Situ: Evidence of a Common Origin

Cui, Shijun; Lespinasse, Pierre; Cracchiolo, Bernadette; Sama, Jahir; Kreitzer, Michael S.; Heller, Debra S.

doi:10.1097/00004347-200107000-00016

Cited by 21 publications

(17 citation statements)

References 3 publications

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“…Then, (1) the hyperplasia of NE cells leads to NEC accompanied by EGD, (2) the malignant transformation of only the glandular epithelium leads to AIS or invasive adenocarcinoma, sometimes accompanied by increasing NE cells, and (3) both the hyperplasia of NE cells and the malignant transformation of the glandular epithelium lead to NEC combined with AIS or invasive adenocarcinoma. These phenomena are reported here and in some other documents [17,18,19,20]. However, the hypothesis needs to be further confirmed by molecular mechanism studies.…”

Section: Discussionsupporting

confidence: 86%

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Zhu

2012

Acta Cytologica

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Objective: Neuroendocrine carcinoma (NEC) of the uterine cervix is a highly aggressive type of tumor. Therefore, recognition of its cytology and histopathology is important for early diagnosis. Study Design: We report 6 cases of small-cell and 6 cases of large-cell NEC of the uterine cervix, including 5 cytology slides. AE1/3, CEA, p63, p16, CD56, chromogranin and synaptophysin were detected. Results: Two cytology slides of small-cell NEC showed sheet-like clusters. The tumor cells were uniformly small, with finely granular chromatin, scant cytoplasm and absent nucleoli. Three large-cell NEC smears showed palisading, molding and abortive rosettes with prominent eosinophilic nucleoli. The tumor cells had either abundant cytoplasm or no cytoplasm at all. The histopathology analysis indicated a transition from dysplasia glands or adenocarcinoma in situ glands to NEC in 6 cases. Conclusion: Cervical cytology of NEC has many unique characteristics, distinct from the characteristics of other lesions. We also demonstrated a hypothesis of the histogenesis of some NECs.

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Section: Discussionsupporting

confidence: 86%

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Zhu

2012

Acta Cytologica

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“…Although LCNEC and combination tumors of the cervix are uncommon, there have been reports of large cell carcinoma coexisting with AIS. 4,6 The fact that scattered neuroendocrine cells were identified among the columnar epithelium in the endocervical glands points toward a similar histogenesis of these 2 malignant components. The neuroendocrine component most likely developed from neuroendocrine cells occurring in the normal endocervix or from stimulated multipotential precursor cells of the endocervical epithelium undergoing neuroendocrine metaplasia or hyperplasia, thereby making the cervical lesion a combination, rather than collision tumor.…”

Section: A B C Dmentioning

confidence: 97%

“…The neuroendocrine component most likely developed from neuroendocrine cells occurring in the normal endocervix or from stimulated multipotential precursor cells of the endocervical epithelium undergoing neuroendocrine metaplasia or hyperplasia, thereby making the cervical lesion a combination, rather than collision tumor. [3][4][5]25 The high frequency of in situ and invasive adenocarcinoma coexisting with LCNEC of the cervix also suggests divergent differentiation rather than synchronous carcinomas. The two distinct populations of malignant cells were already present in the cervicovaginal smear except that the true picture was not fully detected at that early juncture.…”

Section: A B C Dmentioning

confidence: 99%

α-Fetoprotein–Producing Liver Carcinomas of Primary Extrahepatic Origin

Wee¹,

Thamboo²,

Thomas³

2003

Acta Cytologica

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“…Most of these tumors contain foci of in situ or invasive adenocarcinoma . Since both tumor components are positive for chromogranin, they are most likely of common origin with divergent differentiation (Cui et al 2001). …”

Section: Adenoid Basal Carcinoma [8092/3]mentioning

confidence: 99%

Color Atlas of Histopathology of the Cervix Uteri

Dallenbach-Hellweg¹,

Doeberitz²,

Trunk³

2006

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The new edition of this atlas integrates all significant advances made in the past 15 years in molecular pathology, tumor virology, and genetics of cervical cancer. It emphasizes the importance of these advances in facilitating its pathological diagnosis and in optimizing clinical management and prognosis. A new chapter on immunohistochemistry has been added, which includes refined detection methods, e.g., the overexpression of p16INK4a as a molecular marker in the early differential diagnosis of premalignant lesions. The section on etiology and pathogenesis in human papillomavirus-induced neoplasia has been incorporated to represent new insights into the sequences of cellular and nuclear deregulation at the molecular level. All chapters have been revised to include the newest advances and relevant experiences in how to interpret and manage cervical disease; they are supported by the addition of 35 new microphotographic illustrations. The tumor nomenclature is adapted to the latest edition of the WHO classification; the morphology code of the international classification of diseases for oncology (ICD-O) has been added. We have also updated the list of references by adding recent relevant publications.Again, the staff of Springer-Verlag deserve our thanks for their patience and skill in preparing the manuscript and in reproducing the microphotographs. Preface to the First Edition During the past decade our understanding of the histopathology of the cervix uteri has changed greatly. Because of the lifestyles of the modern permissive society, cervical viral infections have become epidemic, resulting in inflammatory and precancerous lesions that were uncommon but now are seen mainly in the younger age groups with increasing frequency. Then too, progress in molecular biology and immunohistochemistry has enabled us to distinguish subtypes of papilloma viruses, to proceed in understanding their action within the genome, and to trace the infected metaplastic and neoplastic-transformed cells to their histogenetic origins. The resultant refined classification of cervical neoplasias has helped to predict clinical outcome and to choose type of therapy.This atlas is intended for all pathologists, to aid them in their routine diagnostic work. We hope it explains just how comprehensive, important and complex the histopathology of the cervix uteri has become during the last few years. It covers all pertinent differential diagnostic aspects and describes in detail how to reach the correct diagnosis. The atlas is also meant for the clinician, to guide him in his often difficult decision of how to provide optimal care for the frequently young patient, who desires children but is at risk for cancer. In particular, the atlas is designed to foster an improved dialogue between the pathologist and the clinician.The microphotographs were selected from our daily diagnostic material, since they show best the technical variations confronting the clinical pathologist in his daily routine, where effects of specimen transport, differences in ...

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Large Cell Neuroendocrine Carcinoma of the Cervix Associated with Adenocarcinoma In Situ: Evidence of a Common Origin

Cited by 21 publications

References 3 publications

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

Twelve Cases of Neuroendocrine Carcinomas of the Uterine Cervix: Cytology, Histopathology and Discussion of Their Histogenesis

α-Fetoprotein–Producing Liver Carcinomas of Primary Extrahepatic Origin

Color Atlas of Histopathology of the Cervix Uteri

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