Large-cell Neuroendocrine Carcinoma of the Skin, With Lymphoid Stroma

Kasami, Masako; Muramatsu, Kouji; Kawahata, Kazuhiro; Yoshikawa, Shusuke; Kiyohara, Yoshio

doi:10.1097/dad.0b013e318159b45e

Cited by 19 publications

(16 citation statements)

References 13 publications

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“…Two other similar cases of an MCC with a follicular lymphocytic infiltrate were recently described [4]. Kasami et al [11] have reported a new entity that they called large cell neuroendocrine carcinoma of the skin; the two cases they described showed an abundant lymphocytic infiltration making the differential diagnosis difficult with MCC mimicking LEL carcinoma and especially an LEL carcinoma of the skin. In this proposed new entity, tumor cells are larger and more pleomorphic than those of conventional MCC, and the characteristic perinuclear immunostaining with cytokeratin 20 is not found.…”

Section: Discussionmentioning

confidence: 97%

Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

Abdelkrim

Dhouibi

Moussa

et al. 2011

Case Reports in Pathology

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Merkel cell carcinoma (MCC) or primary neuroendocrine carcinoma of the skin is a rare neoplasm with aggressive behavior. Primary lymphoepithelioma-like (LEL) carcinoma of the skin is a recently described exceptional tumor, with a relatively good prognosis, and is characterized by a neoplastic epithelial component associated with a dense lymphoid stroma. Rarely, MCC shows a marked lymphocytic host response or can even mimic a LEL carcinoma. We report a new case of MCC mimicking an LEL carcinoma in a 72-year-old male; the diagnosis of MCC was made on the basis of the morphology and immunohistochemical findings. We present through this case an exceptional pattern of MCC which can be misleading, and we insist on differential diagnoses.

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Section: Discussionmentioning

confidence: 97%

Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

Abdelkrim

Dhouibi

Moussa

et al. 2011

Case Reports in Pathology

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“…Another entry to the group came in the form of EMPSGC, first described in 1997 and later found to be the likely precursor of mucinous carcinoma of the skin . The most recently described and least recognized subset of primary cutaneous neuroendocrine tumors, and the focus of this communication, is that of LCNCS …”

Section: Discussionmentioning

confidence: 99%

Primary large cell neuroendocrine carcinoma of the skin: An under‐recognized entity and a mimic of metastatic disease

et al. 2017

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Primary large cell neuroendocrine carcinomas of the skin are exceptionally rare and can be diagnosed only when a metastasis from another organ has been excluded. We report the case of a 62-year-old woman with a cutaneous papule on the mid-chest which generated a differential diagnosis of vascular lesion and basal cell carcinoma. Following excision, microscopic evaluation revealed a dermal large cell undifferentiated carcinoma, with a brisk mitotic rate and focal geographic necrosis. Mucin production was absent. On immunohistochemistry, the lesion expressed CK7, AE1AE3, CK8/18, chromogranin, synaptophysin, CD56, calcitonin (patchy) and TTF-1 (minimal focal). Stains for neurofilament, CK20, CK5/6, p40, p63, SOX10, MART-1, EMA, CEA, ER/PR, GATA3, GCDFP, mammoglobin, PAX-8, CDX2, napsin, ERG and MCPyV proved negative. The histopathological diagnosis was of a large cell neuroendocrine carcinoma, probably metastatic. The patient underwent comprehensive clinical, laboratory and radiographic investigations and no underlying primary carcinoma was detected. During a 20-month followup period with an oncologist, the patient remains well and free of any apparent carcinoma. This suggests a primary large cell neuroendocrine carcinoma of skin. To date, 3 such cases have been reported in Japanese patients. This is the first in a Caucasian resident of North America. | CASE REPORTA 62-year-old woman, with rheumatoid arthritis controlled on adalimumab, sought medical attention because of an erythematous papule on the mid chest. The clinical differential diagnosis included

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“…Up to now, the majority of case reports concerning cNEC of the external ear are diagnosed as MCC, which possesses similar clinical, pathological, and immunohistochemical characteristics to small cell neuroendocrine carcinoma. However, cases of both cutaneous endocrine adenoma [3] and large cell cNEC [5] occurring in external ear have also been reported, which indicates that MCC is not the only type of neuroendocrine tumor of the external ear. Also, considerable debates on the proper name of this tumor still exist because no concrete evidence has been found to prove whether cNEC is derived from epidermal Merkel cells, dermal neuroendocrine cells, or pluripotent dermal stem cells.…”

Section: Discussionmentioning

confidence: 99%

“…Much less often, cNEC is diagnosed in the external ear. To our best knowledge, only 23 cases of cNEC of the external ear have been reported [2–5], and only 3 of them were found in the external auditory canal [6, 7]. …”

Section: Introductionmentioning

confidence: 99%

Cutaneous Neuroendocrine Carcinoma of the External Auditory Canal: A Case Report and Review of the Literature

Chi

Wang

et al. 2012

Case Reports in Otolaryngology

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Cutaneous neuroendocrine carcinoma (cNEC) is rarely seen in the external ear. In this paper, we newly describe a patient with cNEC in his right external auditory canal, followed by a further discussion on the clinical features, diagnosis, and treatments of cNEC of the external ear. A review of the literature showed that cNEC of the external auditory canal generally presents as asymptomatic and that pathology yields the most confirmative diagnosis. A wide resection with adjuvant radiotherapy and chemotherapy is recommended. The overall prognosis of this condition is poor.

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Large-cell Neuroendocrine Carcinoma of the Skin, With Lymphoid Stroma

Cited by 19 publications

References 13 publications

Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

Merkel Cell Carcinoma with Lymphoepithelioma-Like Pattern: A Case Report of an Exceedingly Rare Variant of Merkel Cell Carcinoma with Lymph Node Metastases at Presentation

Primary large cell neuroendocrine carcinoma of the skin: An under‐recognized entity and a mimic of metastatic disease

Cutaneous Neuroendocrine Carcinoma of the External Auditory Canal: A Case Report and Review of the Literature

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