Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples

Alemany, Laia; Saunier, Maëlle; Tinoco, Leopoldo; Quirós, Beatriz; Alvarado‐Cabrero, Isabel; Alejo, María; Joura, Elmar A.; Maldonado, Paula; Klaustermeier, Joellen; Salmerón, Jorge; Bergeron, Christine; Petry, Karl Ulrich; Guimerà, Núria; Clavero, Omar; Murillo, Raúl; Clavel, Christine; Wain, V.; Geraets, D.T.; Jach, Robert; Cross, Paul; Carrilho, Carla; Molina, Claudio; Shin, Hai‐Rim; Mandys, Václav; Nowakowski, Andrzej; Vidal, August; Lombardi, Luis Estuardo; Kitchener, Henry C; Sica, Adela; Magaña-León, Claudia; Pawlita, Michael; Quint, Wim; Bravo, Ignacio G.; Muñóz, Núbia; Sanjosé, Sílvia de; Bosch, F. Xavier

doi:10.1016/j.ejca.2014.07.018

Cited by 157 publications

(133 citation statements)

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“…All of these cases were HR-HPV positive, all primarily had VAIN grade 3. One of the largest international studies about HR-HPV prevalence in VAIN and vaginal cancer showed HPV DNA in 303 of 408 (74 %) invasive cancers and in 181 of 189 (96 %) VAIN 2/3 [11]. This underlines the important influence of HR-HPV on the prognosis of VAIN.…”

Section: Discussionmentioning

confidence: 78%

Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia

Jentschke

Hoffmeister

Soergel

et al. 2015

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 78%

Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia

Jentschke

Hoffmeister

Soergel

et al. 2015

Arch Gynecol Obstet

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“…Persistent high-risk human papillomavirus (HR-HPV) infection is now a well-recognized risk factor for a significant proportion of carcinomas of the anogenital area, including cervical, vaginal, vulvar, penile, and anal cancers, and for a subset of head and neck carcinomas [6][7][8][9][10]. Regarding the latter, oropharyngeal SCC, affecting mostly the palatine tonsils and root of the tongue, shows the strongest, although highly variable association with HR-HPV infection [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis

et al. 2015

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The aim of the study was to investigate prevalence of high-risk human papillomavirus (HR-HPV) infection in sinonasal carcinomas by immunohistochemistry, in situ hybridization, and polymerase chain reaction, detecting p16(INK4a) protein (p16) expression and presence of both HPV DNA and HPV E6/E7 messenger RNA (mRNA). The study comprised 47 males and 26 females, aged 23-83 years (median 62 years), mostly (67 %) with a squamous cell carcinoma (SCC). Of the tumors, 53 % arose in the nasal cavity, 42 % in the maxillary sinus, and 5 % in the ethmoid complex. The follow-up period ranged 1-241 months (median 19 months). HPV16, HPV18, or HPV35 were detected in 18/73 (25 %) tumors, 17 SCCs, and 1 small cell neuroendocrine carcinoma. There was a strong correlation between results of HPV detection methods and p16 expression (p < 0.005). HPV-positive SCCs occurred more frequently in smokers (p = 0.04) and were more frequently p16-positive (p < 0.0001) and nonkeratinizing (p = 0.02), the latter occurring more commonly in nasal cavity (p = 0.025). Median survival for HPV-positive SCC patients was 30 months, while for HPV-negative SCC patients was 14 months (p = 0.23). In summary, we confirm that HR-HPV is actively involved in the etiopathogenesis of a significant subset of sinonasal SCCs. p16 may be used as a reliable surrogate marker for determination of HPV status also in sinonasal SCCs. Although we observed a trend toward better overall survival in HPV-positive SCCs, the prognostic impact of HPV status in sinonasal carcinomas needs to be elucidated by further studies.

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“…Those concerning prevalence and risk factors, attest a high prevalence ranging from 40 to 96 % depending on the considered population, and listed the most common and known risk factors, such as multiple sexual partners, reproductive age and other STD, including HIV [1,54,58]. Studies characterizing HPV infection, confirmed the presence of high-risk genotypes in patients with cervical cancer and showed no association between HPV and P53 and/or Ki-67 that are instead associated with invasive cervix carcinomas, mainly of the squamous keratinizing histotype [12,57,13,17].…”

Section: What Is Known In Mozambique?mentioning

confidence: 99%

Human papillomavirus (HPV) infection: a Mozambique overview

2016

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Human Papillomavirus is agent of the most common sexually transmitted disease which is able to infect mucosal and cutaneous membranes of the anogenital region, upper aerodigestive tract, and other head and neck mucosal regions. Although mainly HPV infection can be asymptomatic and transient, it may persist and give rise to various lesions such as warts, condyloma dysplasia and cancers depending on low or high risk type of HPV infection. Moreover, growing recent evidence suggests a role of this virus in male and female fertility. To date no effective prevention, test, treatment and control strategies are provided for people in developing countries despite the reported high incidence of HPV both in women and men. This paper reviews the more recent literature about HPV infection highlighting epidemiology, related pathologies and possible fertility effects of HPV in male and female with particular attention to the Mozambique context.

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Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples

Cited by 157 publications

References 20 publications

Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia

Clinical presentation, treatment and outcome of vaginal intraepithelial neoplasia

The presence of high-risk human papillomavirus (HPV) E6/E7 mRNA transcripts in a subset of sinonasal carcinomas is evidence of involvement of HPV in its etiopathogenesis

Human papillomavirus (HPV) infection: a Mozambique overview

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