Large diameter microbubbles produced by a catheter-sized microfluidic device for sonothrombolysis applications

Dixon, Adam J.; Shin, Brian; Meka, Vamsi; Kilroy, Joseph P.; Rickel, John-Marschner Robert; Klibanov, Alexander L.; Hossack, John A.

doi:10.1109/ultsym.2015.0122

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…However, microfluidics technology permits real-time, on-chip MB fabrication that, when combined with an IVUS catheter, can provide a fully integrated approach for contrastenhanced IVUS imaging and therapeutic delivery [125]- [127]. Microfluidically-produced MBs have been applied to contrast-enhanced imaging [126]- [129], molecular imaging [130], [131], and therapeutic delivery applications [132]- [134], and a 1.5-mm-diameter catheter-based microfluidic device was recently developed for use in sonothrombolysis applications [135]. On-chip MB fabrication directly within the catheter permits the use of unconventional gases and shell materials, thereby offering the option to modify MB size, concentration, and composition in real-time during an intervention [127], [133], [134].…”

Section: B Integrated Ivus and Mb Catheter Technologiesmentioning

confidence: 99%

Microbubble-mediated intravascular ultrasound imaging and drug delivery

Dixon

Kilroy

Dhanaliwala

et al. 2015

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Intravascular ultrasound (IVUS) provides radiation-free, real-time imaging and assessment of atherosclerotic disease in terms of anatomical, functional, and molecular composition. The primary clinical applications of IVUS imaging include assessment of luminal plaque volume and real-time image guidance for stent placement. When paired with microbubble contrast agents, IVUS technology may be extended to provide nonlinear imaging, molecular imaging, and therapeutic delivery modes. In this review, we discuss the development of emerging imaging and therapeutic applications that are enabled by the combination of IVUS imaging technology and microbubble contrast agents.

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