The implementation of renewable energies represents a crucial step in meeting the sustainable development goal of the United Nations for affordable and clean energy. The Terminos Lagoon region in Campeche, the largest coastal lagoon in Mexico, offers potential for renewable energy sources such as wind, photovoltaic, and current energy. This study presents a renewable energy potential assessment for the main city at Terminos Lagoon, Ciudad del Carmen, which has the largest oil activity in Mexico and high electricity consumption. The outputs of high-resolution numerical models were analyzed to evaluate wind and photovoltaic resources and currents. A hybrid system consisting of 24 wind turbines, 5516 photovoltaic panels, and 32 hydrokinetic turbines could generate 521.33 GWh, which is 39.63% of the state’s energy demand and exceeds the energy consumption of Ciudad del Carmen by 10.24%. Wind and photovoltaic energy are the most significant contributors (517.15 GWh and 3.77 GWh, respectively), while hydrokinetic energy contribution is marginal (0.407 GWh) and requires further research and development. The results suggest that the region has the potential for clean and renewable energy technologies to reduce greenhouse gas emissions and contribute to the energy transition.