Large Doses of Ascorbic Acid in Treatment of Vitamin C Deficiencies

Kyhos, Emma D.; Sevringhaus, Elmer L.; Hagedorn, Dorothy

doi:10.1001/archinte.1945.00210300053006

Cited by 14 publications

(3 citation statements)

References 11 publications

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“…Many other uses of Vit-C include hepatitis, herpes, chickenpox and measles, infectious mononucleosis, trichinosis, urethritis, Antabuse, arthritis, and cancer. Vit-C is also helpful for the treatment of elevated cholesterol and arteriosclerosis, [27][28][29][30][31][32], corneal ulcers, glaucoma, burns, heatstroke, sunburn, slipped disc, toxins, and heavy metal poisonings [33][34][35]. The appropriate clinically effective vaccines and specific antivirals may serve effectively if they are available.…”

Section: Introductionmentioning

confidence: 99%

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

2020

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Section: Introductionmentioning

confidence: 99%

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

2020

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“…The therapeutic potential of ascorbic acid in leukemia have been known for several decades. In particular, the observation that leukemic patients display low vitamin C plasma levels, due to the increased uptake by the actively proliferating leukocytes (Stephens and Hawley, 1936;Kyhos et al, 1945;Barkhan and Howard, 1958) suggested the rationale for the use of high-doses of ascorbic acid, not only as a prophylactic measure, but also to treat a number of pathologic conditions, including cancer (Pauling, 1980). Its role as an anti-cancer agent has long been debated and the identification of potential mechanisms through which ascorbate exerts its biologic and pharmacologic activities, lead to hypothesize a new window of therapeutic opportunities.…”

Section: Discussionmentioning

confidence: 99%

The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia

Travaglini

Gurnari

Antonelli

et al. 2022

Front. Cell Dev. Biol.

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Data derived from high-throughput sequencing technologies have allowed a deeper understanding of the molecular landscape of Acute Myeloid Leukemia (AML), paving the way for the development of novel therapeutic options, with a higher efficacy and a lower toxicity than conventional chemotherapy. In the antileukemia drug development scenario, ascorbic acid, a natural compound also known as Vitamin C, has emerged for its potential anti-proliferative and pro-apoptotic activities on leukemic cells. However, the role of ascorbic acid (vitamin C) in the treatment of AML has been debated for decades. Mechanistic insight into its role in many biological processes and, especially, in epigenetic regulation has provided the rationale for the use of this agent as a novel anti-leukemia therapy in AML. Acting as a co-factor for 2-oxoglutarate-dependent dioxygenases (2-OGDDs), ascorbic acid is involved in the epigenetic regulations through the control of TET (ten-eleven translocation) enzymes, epigenetic master regulators with a critical role in aberrant hematopoiesis and leukemogenesis. In line with this discovery, great interest has been emerging for the clinical testing of this drug targeting leukemia epigenome. Besides its role in epigenetics, ascorbic acid is also a pivotal regulator of many physiological processes in human, particularly in the antioxidant cellular response, being able to scavenge reactive oxygen species (ROS) to prevent DNA damage and other effects involved in cancer transformation. Thus, for this wide spectrum of biological activities, ascorbic acid possesses some pharmacologic properties attractive for anti-leukemia therapy. The present review outlines the evidence and mechanism of ascorbic acid in leukemogenesis and its therapeutic potential in AML. With the growing evidence derived from the literature on situations in which the use of ascorbate may be beneficial in vitro and in vivo, we will finally discuss how these insights could be included into the rational design of future clinical trials.

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“…The increased requirement for ascorbate in cancer can also be demonstrated by ascorbate loading tests (18,49,126,127,186,217). All such investigations have shown an increased utilization of ascorbate by the cancer subjects.…”

Section: The Increased Requirement For Ascorbic Acid In Cancermentioning

confidence: 93%

Orthomolecular Medicine

McLeay¹

2001

World Scientific Series in 20th Century Chemistry

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Large Doses of Ascorbic Acid in Treatment of Vitamin C Deficiencies

Cited by 14 publications

References 11 publications

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

The Anti-Leukemia Effect of Ascorbic Acid: From the Pro-Oxidant Potential to the Epigenetic Role in Acute Myeloid Leukemia

Orthomolecular Medicine

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