Large Doses of Vitamin D Fail to Increase 25-Hydroxyvitamin D Levels or to Alter Cardiovascular Risk Factors in Obese Adolescents: A Pilot Study

Shah, Saloni; Wilson, Darrell M.; Bachrach, Laura K.

doi:10.1016/j.jadohealth.2015.02.006

Cited by 42 publications

(24 citation statements)

References 32 publications

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“…We have previously shown that 50 000 IU vitamin D weekly and 1 000 mg calcium daily cosupplementation for 8 weeks among overweight and vitamin D-deficient patients with PCOS decreased serum hs-CRP levels [11]. Supplementation with vitamin D did not alter inflammatory markers among overweight and obese youth for 24 weeks [29] and among subjects with pre-diabetes and hypovitaminosis D for 12 months [30]. In addition, Kim et al [31] have shown that serum hs-CRP levels were positively associated with vitamin K deficiency in young adult women.…”

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confidence: 85%

The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2016

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The current study was conducted to assess the effects of vitamin D-K-calcium co-supplementation on endocrine, inflammation, and oxidative stress biomarkers in vitamin D-deficient women with polycystic ovary syndrome (PCOS). This randomized double-blind, placebo-controlled trial was performed on 60 vitamin D-deficient women diagnosed with PCOS aged 18-40 years old. Participants were randomly allocated into 2 groups to intake either 200 IU vitamin D, 90 μg vitamin K plus, 500 mg calcium supplements (n=30), or placebo (n=30) twice a day for 8 weeks. Endocrine, inflammation, and oxidative stress biomarkers were quantified at the beginning and the end of the study. After 8 weeks of intervention, compared with the placebo, vitamin D-K-calcium co-supplementation resulted in a significant reduction in serum-free testosterone (- 2.1±1.6 vs.+0.1±1.0 pg/ml, p<0.001) and dehydroepiandrosterone sulfate (DHEAS) levels (- 0.8±1.0 vs.-0.1±0.5 μg/ml, p=0.006). In addition, a significant increase in plasma total antioxidant capacity (TAC) (+ 75.7±126.1 vs.-80.4±242.8 mmol/l, p=0.005) and a significant difference in plasma malondialdehyde (MDA) concentrations (+ 0.03±0.6 vs.+1.4±2.4 μmol/l, p=0.005) was observed following the supplementation with vitamin D-K-calcium compared with the placebo. A trend toward a greater decrease in luteinizing hormone was observed in vitamin D-K-calcium co-supplement group compared to placebo group (- 7.0 vs.-1.2 IU/l, p=0.09). We did not find any significant effect of vitamin D-K-calcium co-supplementation on prolactin, follicle-stimulating hormone, 17-OH progesterone, inflammatory markers, and glutathione levels. Overall, vitamin D-K-calcium co-supplementation for 8 weeks among vitamin D-deficient women with PCOS had beneficial effects on serum DHEAS, free testosterone, plasma TAC, and MDA levels.

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confidence: 85%

The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

et al. 2016

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“…Some, but not all, studies describe a similar association between 25(OH)D and inflammatory markers in HIV [17][18][19]. Increasing 25(OH)D levels through supplementation has a favourable effect on BMD [20] and cellular immune activation levels [21], though less evidence exists for other inflammatory markers associated with cardiovascular risk [22,23].…”

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confidence: 99%

Effects on Vitamin D, Bone and the Kidney of Switching from Fixed-Dose Tenofovir Disoproxil Fumarate/Emtricitabine/Efavirenz to Darunavir/ Ritonavir Monotherapy: A Randomized, Controlled Trial (MIDAS)

Hamzah¹,

Tiraboschi²,

Iveson³

et al. 2015

Antiviral Therapy

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“…Shah et al [4] carried out a trial relevant to this important area of research in this issue of the Journal of Adolescent Health. Previous investigation has proposed insufficient serum 25-hydroxyvitamin D (25OHD) to be a contributor to vascular complications in obese children, with evidence provided by Codoñer-Franch et al [3] including increased markers of oxidative stress, inflammation, and endothelial activation in that population.…”

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confidence: 99%

The Weight of Vitamin D on Obesity Outcomes: What Do We Know?

Bialo

Gordon

2015

Journal of Adolescent Health

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Large Doses of Vitamin D Fail to Increase 25-Hydroxyvitamin D Levels or to Alter Cardiovascular Risk Factors in Obese Adolescents: A Pilot Study

Cited by 42 publications

References 32 publications

The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

The Effects of Vitamin D-K-Calcium Co-Supplementation on Endocrine, Inflammation, and Oxidative Stress Biomarkers in Vitamin D-Deficient Women with Polycystic Ovary Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial

Effects on Vitamin D, Bone and the Kidney of Switching from Fixed-Dose Tenofovir Disoproxil Fumarate/Emtricitabine/Efavirenz to Darunavir/ Ritonavir Monotherapy: A Randomized, Controlled Trial (MIDAS)

The Weight of Vitamin D on Obesity Outcomes: What Do We Know?

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