Geometric models of a lobed mixer nozzle with variation of lobe spacing ratios are created and the corresponding flow fields are simulated using a steady Reynolds Averaged Navier-Stokes (RANS) equation with a realizable k-ε turbulence model and standard wall function. According to the numerical simulation results, the spacing ratio has a large influence on the shape of streamwise vortices, but a relatively small effect on the streamwise vorticity field at the lobe exit. Therefore, at the initial part of mixing, a change of spacing ratio has little effect on the thermal mixing efficiency and the total pressure recovery coefficient. In addition, the thermal mixing efficiency increases sharply at the initial part, and near the nozzle exit it approaches some constant. The development of the total pressure recovery coefficient is totally reverse to the thermal mixing efficiency. It falls rapidly at the beginning. Then the rate of descent gradually slows down, and approaches some constant. At the nozzle exit cross-section, the thermal mixing efficiency ascends and the total pressure recovery efficiency reduces as the spacing ratio increases. Besides, the thrust coefficient has little relationship to the spacing ratio, with a variation smaller than 0.01 when the spacing ratio increases from 4.87 to 0.497.