In order to reduce the number of prototypes during product design and accurately predict unsteady phenomena occurring at off-design points, a method for accurately predicting the performance of centrifugal blowers through numerical analysis is required. This paper presents a guideline for accurately predicting the performance of centrifugal blowers using compressible flow analysis with Large Eddy Simulation (LES). In LES analysis, it is important to have a grid resolution that resolves the minimum vortex scale near the wall (referred to as wall-resolved LES) and to consider detailed geometry such as the length of the suction pipe. The calculations in this study used a model blower, which is a scale model of a single-stage centrifugal blower for use in industrial plants. The model blower was experimentally measured for various parameters such as the blower pressure coefficient, the static pressure rise coefficients of the impeller and vane-less diffuser, the shaft power, and the pressure fluctuations at the inlet of the impeller and the inlet of the vane-less diffuser. The results of these measurements were compared with those obtained from the wall-resolved LES. The study confirmed that the accuracy of performance prediction can be improved to less than a 4.0% error in the blower pressure coefficient at both design and off-design operating points by resolving the minimum vortex scale with 14.6 billion grid elements and considering the detailed geometry.