To investigate the cavitation and hydrodynamic characteristics of supercavitating projectiles in the shear flow, the Mixture multiphase and Schnerr-Sauer cavitation models are employed to simulate the underwater projectiles. The inflow average velocity is 600 m/s, and the shear rates range from 0 to 7500 s−1. In the uniform flow, the supercavity enveloping projectiles is vertically symmetrical. The drag is dominated by pressure drag, and the lift coefficient is 0. However, the supercavity is asymmetric in the shear flow, which deviates towards the low-speed side of projectiles. This is because the flow around projectiles runs faster on the high-speed side, and the vortices on the low-speed side entrain more fluid from the high-speed side. Thus, the projectiles suffer from normal shear stress orientating towards the low-speed side, and the lift coefficient turns negative. When the shear rate further increases, the projectile shoulder contacts water on the high-speed side, and the viscosity around projectiles is enhanced, resulting in the significant augmentation of the drag coefficient. As the water pressure is strongly larger than saturated vapor pressure on the low-speed side, the normal component of pressure acts more intensely towards the low-speed side of projectiles, and the lift coefficient is further decreased.