The inter-flat airborne cross-transmission driven by single-sided natural ventilation has been identified recently in high-rise residential buildings, where most people live now in densely populated areas, and is one of the most complex and least understood transport routes. Given potential risks of infection during the outbreak of severe infectious diseases, the need for a full understanding of its mechanism and protective measures within the field of epidemiology and engineering becomes pressing. This review paper considers progress achieved in existing studies of the concerned issue regarding different research priorities. Considerable progress in observing and modeling the inter-flat transmission and dispersion under either buoyancy-or wind-dominated conditions has been made, while fully understanding the combined buoyancy and wind effects is not yet possible. Many methods, including on-site measurements, wind tunnel tests and numerical simulations, have contributed to the research development, despite some deficiencies of each method. Although the inter-flat transmission and dispersion characteristics can be demonstrated and quantified in a time-averaged sense to some extent, there are still unanswered questions at a fundamental level about transient dispersion process and thermal boundary conditions, calling for further studies with more advanced models for simulations and more sound experiments for validations. Nomenclature v 1 , v 2 , v 3 , v 4 approaching wind speed (m/s) V flat volume (m 3 ) C tracer gas concentration (ppm) C * number of infection cases Greek symbol H c recirculation cavity height (m) ε turbulence viscous dissipation rate (m 2 /s 3 ) I number of infectors θ incident wind angle (°) k turbulent kinetic energy (m 2 /s 2 ) ν kinematic viscosity (m 2 /s) L length of the building (m) L r distance of the recirculation zone (m) Abbreviation M i-j mass fraction ACH hourly air exchange rate (h -1 ) P probability of infection CFD computational fluid dynamics p pulmonary ventilation rate of a person (m 3 /h) HRR high-rise residential Q room ventilation rate (m 3 /h) IAQ indoor air quality Q e a portion of the infected airflow which escapes from the upper part window of the lower room LES large-eddy simulation MERS middle east respiratory syndrome q quanta generation rate RANS Reynolds-averaged Navier-Stokes R scaling length that characterizes the building's influence on wind flow (m) RNG renormalization group SARS severe acute respiratory syndrome R k re-entry ratio (%) S number of susceptibles Subscript t exposure time interval (h) i source flat U H mean speed of wind approaching the building at H (m/s) j target flat