The big cats are of paramount importance for the sustenance of ecosystems and their interaction with humans is critical for their conservation. Coexistence and tolerance of the people involved will be crucial in the conservation of these cats in the growing human-dominated landscapes. The literature review on humans and big cats' conflicts and their coexistence indicates socio-economic factors are the main driving forces in shaping human attitudes toward these cats. In contrast to the mainstream view, conflict frequency does not directly affect the tolerance capacity of stakeholders; instead, coalitions of many factors like livelihood status, religious and cultural beliefs and government intervention are involved. The review provides an evaluation of the prevalent mitigation measures and other principles that govern human-big cats conflict and sheds light on the potential of coexistence as a pro-conservation strategy.