Large Fibroid arising from Mullerian Remnant Mimicking as Ovarian Neoplasm in a Woman with MRKH Syndrome

Singh, Soma; Chakravarty, Baidyanath; Chakravarty, Manju; Chakravarty, A.

doi:10.5005/jp-journals-10016-1037

Cited by 6 publications

(3 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4][5][6][11][12][13] Differential diagnosis of leiomyoma of rudimentary uterus in MRKH syndrome includes ovarian fibroma, gastrointestinal stromal tumor (GIST) of intestine and extravesical leiomyoma of urinary bladder. The uncommon occurrence of leiomyoma in MRKH may be explained by decreased concentration or sensitivity of estrogen receptors in the rudimentary tissue.…”

Section: Discussionmentioning

confidence: 99%

“…1 Occurrence of a myoma arising from a mullerian remnant is an extremely rare finding and only few cases reported in literatures. [1][2][3][4][5][6] The incidence of associated urologic abnormalities ranges between 15-40%, and skeletal anomalies such as congenital fusion or absence of vertebra occur in approximately 12-50% of cases. Unilateral renal anomalies are associated with 50% of the patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Fibroid with unilateral streak ovary in Mullerian Agenesis!a rare case report

Malik¹,

Goyal

Bhardawaj

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare anomaly (1/5000) associated with uterine and vaginal aplasia with normal ovaries. A fibroid in a normal uterus is common but a fibroid arising from rudimentary horn in Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is very rare. It is also rare to have the association of unilateral ovarian dysgenesis in MRKH. A 37 year old married female with primary amenorrhea presented to the OPD of Dr. RML Hospital with abdominopelvic mass for one year. She was phenotypically normal looking and there was no other associated cardiac, ocular or skeletal abnormality. A large 15 × 15 cm abdominopelvic mass was present in suprapubic area which was firm in consistency and non-tender. A Two and a half inch long blind vaginal pouch was present with absence of cervix and uterus. A provisional diagnosis of solid ovarian tumor in MRKH syndrome was made. Her investigations -Serum FSH, LH, estradiol and tumor markers were normal. Her ultrasound and MRI reported a fibroid with normal ovaries. Laparotomy revealed absence of uterus and cervix and a large fibroid arising from right rudimentary horn with left streak ovary. Right ovary was enlarged to 4 × 4 cm, showing multiple small follicles. Fibroid along with the rudimentary horns and the streak ovary was removed, preserving the normal right ovary. Histopathology confirmed the diagnosis of leiomyoma in rudimentary horn with left streak ovary, making it class1 type b anomaly under American fertility society classification. Preoperative assessment of rare anomalies can be different from intraoperative findings in certain female reproductive tract anomalies. Awareness of rare combinations can help in judicious management of such cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fibroid with unilateral streak ovary in Mullerian Agenesis!a rare case report

Malik¹,

Goyal

Bhardawaj

2018

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

show abstract

“…The removal of the symptomatic tumor with the adjacent uterine remnant is indicated which can be done laparoscopically. 7,8 …”

Section: Discussionmentioning

confidence: 99%

Fibroid originated from rudimentary horn in mullerian agenesis

Deepika

Gupta

Wadhwa

et al. 2017

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

Mullerian agenesis or Mayer Rokitansky- Kuster- Hauser syndrome is defined by congenital absence of both the uterus and vagina. It affects 1 in 4000-5000 females. Leiomyoma arising from the uterine remanent in case of MRKH is very rare. Very few cases have been reported in literature. The exact etiopathogenesis of leiomyoma from the rudimentary uterus in MRKH syndrome is not known. We are reporting a rare case of 35-year-old married, nulliparous female who presented with primary amenorrhea and lump in lower abdomen since, 1 year. On physical examination, a mass of 18-week size of uterus, firm in consistency, irregular, nontender, mobile from side to side, occupying right iliac and hypogastric region was detected. Provisional diagnosis of multiple leiomyoma with mullerian anomaly was made on USG and MRI for which laparotomy was performed. Per-operatively, there was a mass of approx. 15 x 8 x 8 cm consisting of multiple fibroids present, uterus not visualized separately. Right ovary and tube absent. Left fallopian tube and ovary were normal arising from left rudimentary horn with no endometrial tissue. Blind end with no cervix. Partial agenesis of vagina. No communication possible between rudimentary horn and vagina. Patient underwent hysterectomy in view of non-functioning uterus. Histopathology report confirmed the diagnosis. Finally, it was diagnosed as a case of multiple leiomyoma originating from uterine remanent. Post-operative period was uneventful.

show abstract

Mayer‐Rokitansky‐Kuster‐Hauser syndrome with multiple leiomyomas

Vidyashree

Muralidhar

Nambiar

et al. 2014

Intl J Gynecology & Obste

View full text Add to dashboard Cite

stratified based on if one versus multiple cervical sites were sampled (Table 1). There was more disease in quadrants with visible lesions, but a substantial proportion of disease was identified in quadrants without visible lesions.By obtaining a punch biopsy from cervical quadrants with and without visible lesions we estimated the amount of disease typically missed when biopsies are restricted to visible lesions. Approximately one-third of all CIN2 + were from quadrants without visible lesions, analogous to results by Pretorius et al.[4] who reported that 37% of all CIN2 + lesions in HIV-negative women were from colposcopically normal-appearing areas on the cervix. We recommend that screening studies include systematic sampling for histopathology regardless of the screening result, to minimize verification bias in cervical cancer screening trials.

show abstract

Large Fibroid arising from Mullerian Remnant Mimicking as Ovarian Neoplasm in a Woman with MRKH Syndrome

Cited by 6 publications

References 10 publications

Fibroid with unilateral streak ovary in Mullerian Agenesis!a rare case report

Fibroid with unilateral streak ovary in Mullerian Agenesis!a rare case report

Fibroid originated from rudimentary horn in mullerian agenesis

Mayer‐Rokitansky‐Kuster‐Hauser syndrome with multiple leiomyomas

Contact Info

Product

Resources

About