“…Domestic crowding is associated with risk of viral transmission ( 21 , 22 ) and fewer opportunities for isolation at the home, but is, at least partially, accounted for by adjusting for social, ethnic and geographical characteristics including number of household members and children. Nevertheless, information about factors such as home-to-work commuting patterns ( 23 , 24 ), large gathering attendance ( 25 ) and local hotspots ( 26 ) was not available at the individual level and skewed distribution of these factors across exposure categories may have contributed to residual confounding in either direction. The same applies to JEM-based assignment of probability of smoking and body mass index.…”